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SHENZHEN, China, July 19, 2024 /PRNewswire/ -- On July 19, Shenzhen Chipscreen Biosciences Co., Ltd. (hereinafter referred to as "Chipscreen Biosciences") announced that it has received the Drug Registration Certificate approved and issued by the National Medical Products Administration (NMPA) for Chiglitazar, a noval PPAR (Peroxidase Proliferator Activated Receptor) full agonist developed by the company's independently, combined with Metformin for the treatment of type 2 diabetes. This is a further expansion of the clinical application of Chiglitazar after it was approved as a single agent for the treatment of type 2 diabetes in October 2021, and will provide a noval therapeutic option of combination for type 2 diabetes patients. As of 2021, the number of diabetes patients in China has reached 141 million, ranking first globally. Type 2 diabetes accounts for more than 90% of the total. As a progressive disease, it seriously affects the quality of life of patients and causes a heavy burden on society. As the disease progresses, the probability of monotherapy failure in type 2 diabetic patients gradually increases. Researches have shown that 50% of newly diagnosed T2DM patients require combination therapy after three years of treatment for patients with initial diabetes; After 9 years of treatment, 75% of patients require combination therapy; In addition, for newly treated patients with high blood glucose levels, such as HbA1c>9%, combination therapy is often necessary to achieve good glycemic control. Therefore, combination therapy is essential for diabetes patients. Insulin resistance, as one of the important pathological mechanisms of the occurrence and development of type 2 diabetes, has always been a focus and challenge of drug development and clinical treatment. It will not only cause hyperglycemia but also lead to hyperlipidemia, overweight/obesity, fatty liver, atherosclerotic cardiovascular disease, etc. Now, Chiglitazar has been approved for adjunction to metformin to improve glycemic control in patients with type 2 diabetes with poor blood glucose control after metformin monotherapy. The randomized, double-blind, placebo-controlled pivotal Phase III clinical trial showed that compared with placebo combined with metformin, Chiglitazar combined with metformin can achieve more clinical benefits such as continuous glucose reduction, blood lipid regulation and cardiovascular risk reduction, which shows the promising application of Chiglitazar in combination with diabetes drugs of different mechanisms. Dr. Xianping Lu, chairman of Chipscreen, said: "Although there are multiple drugs available for the treatment of T2DM, the rapid growth of the number of patients with diabetes indicates that there are still significant unmet clinical needs in this field, whether it is monotherapy or combination therapy. As the first PPAR full agonist approved to treat type 2 diabetes in the world, Chiglitazar with a new mechanism of action has broken the long-term dilemma of etiological treatment of insulin resistance, effectively targeted the metabolic syndrome caused by metabolic disorder, opening up a new path for the treatment of type 2 diabetes and providing clinicians and patients with a more flexible and effective combination drug regimen. About Chiglitazar Chiglitazar (Shuangluoping ®/ Bilessglu ®) is a new mechanism hypoglycemic drug independently developed by Shenzhen Chipscreen Biosciences Co., Ltd. As a new chemical molecule，it belongs to a national Class 1 new drug, national "Major New drug creation" special achievement . It is the first PPAR full agonist which approved for the treatment of type 2 diabetes in the world. Chiglitazar can control blood glucose level and ameliorate the lipid and energy metabolic disorders that accompany T2DM, helping to prevent and control cardiovascular complications. This makes Chiglitazar a potentially more comprehensive treatment option for T2DM. Many basic studies have confirmed that insulin resistance is one of the core pathological mechanisms for the occurrence and development of type 2 diabetes, and it is also the common soil for various metabolic abnormalities such as blood sugar and blood lipid. Insulin resistance will not only cause hyperglycemia, but also lead to hyperlipidemia, overweight/obesity, fatty liver, atherosclerotic cardiovascular disease (ASCVD), etc. However, there are relatively few drug options directly targeting the improvement of insulin resistance in clinical practice. Chiglitazar, a PPAR total agonist, can moderately activate three PPAR receptor subtypes with different functions in regulating glucose, lipid and energy metabolism in vivo, and selectively changes a series of gene expressions related to insulin sensitivity, targeting insulin resistance, the core pathological mechanism of the occurrence and development of type 2 diabetes. Through improving the sensitivity of diabetes patients to insulin, regulating blood sugar, improving their complicated lipid metabolism disorder, potentially reducing the occurrence and harm of cardiovascular complications, bringing better efficacy and safety, and achieving comprehensive treatment of diabetes and its complications. In addition to the indications for type 2 diabetes, Chiglitazar has also carried out clinical exploration of compound preparations of diabetes drugs (metformin-chiglitazar compound, Empagliflozin-chiglitazar compound) and phase II clinical research of single drug treatment of nonalcoholic fatty liver steatohepatitis in China. In October 2021, Chiglitazar was approved by the National Drug Administration (NMPA) to be marketed for the treatment of type 2 diabetes. In January 2023, Chiglitazar was included in the national medical insurance directory. In March 2024, the Phase II clinical trial (CGZ203 study) of Chiglitazar monotherapy for non-alcoholic steatohepatitis achieved the primary efficacy endpoint. In July 2024, the treatment of type 2 diabetes patients with poor blood glucose control after single drug treatment of metformin with Chiglitazar and metformin was approved for marketing by the National Drug Administration (NMPA) of China. About Chipscreen Chipscreen Biosciences is an innovative drug company driven by core technologies with globally competitive pipelines. As a pioneer in drug innovation & development in China, adhering to the concept of "Constant Innovation for Life", we focus on developing revolutionary innovative drugs with new mechanisms of action, to address patients' pressing clinical needs. Chipscreen Biosciences has formed a complete industrial chain covers from early exploratory discovery to commercialization, providing original Chinese new drugs for global patients. Based on the global development strategy of China's early stage research, Chipscreen Biosciences has been able to open the whole process from basic research to clinical transformation with Shenzhen Small Molecule Early R&D Center and Chengdu Small Molecule Early R&D Center bringing together top scientists and teams with senior experience in related fields, and applying the integrated technology platform based on AI-driven design and chemical genomics. We have successfully developed first-in-class and best-in-class innovative drugs. Currently, we have marketed two drugs for four indications in Mainland China, two indications in Japan, and one indication in Taiwan, China. In addition, we have launched a number of R&D projects with differentiated advantages and global competitiveness in the five major areas, including malignant tumors, metabolic diseases, autoimmune diseases, central nervous system diseases, and antivirals. Chipscreen Biosciences has formed a global industrial layout consisting of Shenzhen Head Office/R&D Center/GMP production base, Chengdu Regional Head Office/R&D Center/GMP production base, Beijing Branch, Shanghai Branch, and Chipscreen Biosciences (USA) Co., Ltd. Meanwhile, as one of the first batches of national "innovative drug incubation bases" and national high-tech enterprises, Chipscreen Biosciences has independently undertaken many national "863" plans and national major science and technology projects, such as "10th five-year plan", "11th five-year plan", "12th five-year plan" and "13th five-year plan", and National Science and Technology primary Project for Innovative Drug Development. We have filed over 660 invention patents in China and worldwide, with over 180 granted.
MicuRx showcased the latest research progress on their pipeline products, MRX-5 and MRX-8, at the 7th World Bronchiectasis Conference Three significant study results further support the potential of MRX-5 and MRX-8 in treating Nontuberculous Mycobacteria (NTM) lung disease and Pseudomonas aeruginosa infections DUNDEE, Scotland, July 18, 2024 /PRNewswire/ -- Shanghai MicuRx Pharmaceutical Co., Ltd. ("MicuRx"，688373.SH) presented the latest research progress on their novel antibiotic pipeline products, MRX-5 and MRX-8, at the 7th World Bronchiectasis Conference (WBC) held in Dundee, Scotland, from July 4 to 6, 2024. These research results provide new hope for the future treatment of Nontuberculous Mycobacteria (NTM) lung disease and Pseudomonas aeruginosa infections. Conference Background The World Bronchiectasis Conference is a leading global academic conference focused on the research and treatment of bronchiectasis. This conference brings together top scientists and clinical experts from around the world to discuss the latest research developments, clinical management strategies, and the development of new therapies for bronchiectasis. Research Highlights As a biopharmaceutical company dedicated to developing innovative anti-infective drugs, MicuRx presented three significant research results in poster presentation at the conference. These studies further support the potential of MRX-5 and MRX-8 in the treatment of specific infections： In Vitro and In Vivo Activity of A Novel Leucyl-tRNA Synthetase Inhibitor Against Mycobacterium Abscessus The active drug MRX-6038 was very potent against M. abscessus clinical isolates in vitro with MIC90 0.5 mg/L while the control drug clarithromycin MIC90 was 4 mg/L. MRX-6038 greatly reduced the resistance frequency of standard of care drugs (Ethambutol, Clarithromycin, Rifabutin, Clofazimine, Amikacin, Imipenem, Ciprofloxacin) by more than 10 to 100,000 folds, demonstrating the potential for combination with the background therapy. Oral prodrug MRX-5 was tested in mice with lung infections due to M. abscessus isolates, and efficacy was demonstrated against infections with both clarithromycin-sensitive and clarithromycin non-susceptible isolates. In Vitro Activity of Novel Leucyl-tRNA Synthetase Inhibitor Against Mycobacterium Avium Complex MRX-6038, the major activedrug of MRX-5, has demonstrated potent in vitro activity against Mycobacterium avium clinical isolates including isolates not susceptible to clarithromycin. When MRX-6038 was combined with Clarithromycin, Rifabutin, Amikacin, and Ethambutol, the resistance frequency of these standard of care drugs was greatly reduced to below 6.5×10-11. Further studies are warranted for the evaluation of MRX-6038 for the treatment of Mycobacterium avium pulmonary disease. In Vitro and In Vivo Activity of A Novel Antibiotic In The Polymyxin Class Against Pseudomonas Aeruginosa MRX-8 demonstrated potent in vitro activity against P. aeruginosa including tobramycin and amikacin resistant clinical isolates. In mouse models with P. aeruginosa lung infections of both tobramycin-sensitive and tobramycin-resistant isolates, nebulized MRX-8 treatment significantly decreased bacterial load in the lung tissues, demonstrating bactericidal activity. About MRX-8 MRX-8 is a novel polymyxin antibiotic developed by MicuRx, primarily used to treat severe infections caused by multidrug-resistant Gram-negative bacteria. Traditional polymyxins are limited in clinical use due to nephrotoxicity and neurotoxicity. Through meticulous structural design, MRX-8 not only maintains or enhances therapeutic efficacy but also significantly improves safety by reducing these potential toxic risks. In 2022, MRX-8 completed Phase I clinical trials in the United States. In 2023, it completed Phase I enrollment in China, with primary study results released in June 2024. These trial results indicated that MRX-8 achieved the desired therapeutic levels in the human body at the expected clinical doses for infections caused by Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Besides systemic administration, the company plans to explore the development of an inhaled formulation of MRX-8 to uncover its clinical and commercial value in targeted treatment of chronic lung infections. About MRX-5 and NTM MRX-5 is a novel benzoxaborole antibiotic developed by MicuRx for infections caused by NTM. NTM is a common pathogen causing bronchiectasis. In recent years, the incidence of NTM diseases has rapidly increased, becoming a significant public health issue. [1] Among diseases caused by NTM, Mycobacterium avium complex and Mycobacterium abscessus complex account for 70%-95% of NTM diseases. [2] The main clinical symptoms of NTM pulmonary infections include persistent cough, sputum production, chest pain, shortness of breath, fatigue, weight loss, and malaise. [1] Preclinical data indicates that MRX-5 has good antibacterial activity against most common NTM pathogens and has demonstrated good safety in animal studies. Additionally, its characteristics of minimal drug interactions, low resistance potential, and oral availability make it an ideal candidate for the treatment of chronic infections. Currently, MRX-5 is undergoing Phase I clinical trials, offering a promising new treatment option for patients with NTM diseases. About Shanghai MicuRx Pharmaceutical Co., Ltd. MicuRx is a biopharmaceutical company focusing on novel therapeutics for infectious diseases. With global independent intellectual property and competitiveness, we are committed to the discovery, development, and commercialization of innovative drugs for unmet medical needs. Since the company was founded in 2007, MicuRx has adhered to the principle of "Better therapy through superior medicine", focusing on the increasingly serious problem of global antimicrobial resistance. For more information, please visit our website at www.micurx.com References： [1] Chinese Medical Association Tuberculosis Branch. Guidelines for the Diagnosis and Treatment of Nontuberculous Mycobacterial Diseases (2020 Edition). Chinese Journal of Tuberculosis and Respiratory Diseases, 2020, 43(11): 918-946. DOI: 10.3760/cma.j.cn112147-20200508-00570. [2] Luo Kuo, Chen Shanze, Chen Rongchang, et al. Host Factors of Nontuberculous Mycobacterial Diseases. Chinese Journal of Tuberculosis and Respiratory Diseases, 2022, 45(7): 716-720. DOI: 10.3760/cma.j.cn112147-20211210-00872.
BOSTON, July 17, 2024 /PRNewswire/ -- Immunocan announced the successful construction of new strain of fully human antibody platform: ImmuMab® HKL mouse. This new mouse was created by in-situ replacing the variable region of Immunoglobulin genes of mouse by its counterparts from human. With Lambda light chain genes humanized, ImmuMab® HKL mouse now contains approximately 3.2 Mb of human immunoglobulin variable region genes, making it the humanized mouse with the longest human immunoglobulin variable regions in the world. Since the first mouse-derived monoclonal antibody drug OKT3 (muromonab-CD3) was marketed in 1986, over 120 antibody drugs from different sources have been approved by FDA and brought clinical benefits to patients. Despite flexibility and well-established application process, ritual use of mice during antibody generation brought limitations for drug development space. Due to the low utilization of Immunoglobulin Lambda genes in wildtype mice (about 5%, varying by strain), antibodies with Lambda light chain (λ-antibodies) have always been under-scrutinized. As of December 31, 2023, only 14 FDA-approved antibody drugs contain Lambda light chain, and most of these are from transgenic mice or human antibody library used in display technologies. In humans, naturally occurring λ-antibodies are approximately 35% of the antibody repertoire and plays important role in adaptive immunity. Different individuals generate immune repertoires with different preferences of light chain type in response to different immunogens. Within the immune repertoire against the same antigen, λ-antibodies can target different epitopes from κ-antibodies. Therefore, using an antibody generation model containing human Lambda light chains can significantly enhance the epitope coverage of the immune repertoire and increase the success rate of obtaining candidate antibodies fitting target product profile. By proprietary Massive-fragment Across Species In-situ Replacement Technology (MASIRT®), Immunocan achieved humanization of Lambda light chain variable regions of ImmuMab® mouse, which increased the total humanized immunoglobulin variable region to 3.2 Mb. This innovation provides the industry with source of λ-antibody repertoires of higher diversity and developability compared to existing platforms. For most antigens, especially in the early stage of discovery programs, the light chain preference of preferred lead antibodies is unpredictable. Using mouse generating a significant quantity of human λ-antibodies can prevent the early exclusion of superior lead molecules during antibody generation, increasing the probability of drug development success. In addition to ImmuMab® HKL mouse, Immunocan has already constructed platforms including ImmuMab® HK mouse generating fully human antibody (κ-antibodies), ImmuMab Heavy® mouse generating fully human heavy-chain-only antibody (HCAb), ImmuAlpaca® mouse generating alpaca-derived antibody, and ImmuMab Light® mouse generating fully human common-light-chain antibody. ImmuHeavy® Rabbit is currently under construction to generate rabbit heavy-chain-only antibodies. By continuously innovating in-vivo antibody discovery platforms, Immunocan aims to help partners accelerate the development of novel therapeutics. Immunocan's multi-species antibody generation strategy not only expands the potential for antibody discovery and development but also provides more therapeutic options for treating complex diseases. Immunocan is looking forward to introducing its innovative antibody discovery platforms to global research partners and seek collaboration to bring safer and more effective therapeutic products to patients worldwide. About the Massive-fragment Across Species In-situ Replacement Technology (MASIRT®) Immunocan's core technology features one-step gene replacement at Mb scale between two species. Its advantageous genome-engineering efficiency enables rapid construction of multiple specialized antibody discovery platforms, including mice generating fully human antibodies or alpaca antibodies and rabbits generating fully human antibodies (under construction). About Immunocan Immunocan was founded in 2020 and specializes in using gene editing technology to replace immunoglobulin variable region genes in various animals, resulting in genetically engineered animals capable of producing fully human antibodies and other innovative modalities. The company is committed to offering cutting-edge antibody discovery platforms to worldwide drug research partners, with the goal of developing safer and more effective treatments for human diseases. For more information, please visit: https://immunocan.com/ For business cooperation, please contact: BD@immunocan.com
SHANGHAI, July 16, 2024 /PRNewswire/ -- Sanyou Biopharmaceuticals (Shanghai) Co., Ltd. (hereinafter referred to as "Sanyou Bio") has recently announced a significant milestone in collaboration with Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd., a wholly-owned subsidiary of Huadong Medicine Co., Ltd. (SZ.000963, hereinafter referred to as "Huadong Medicine"). The jointly developed ADC drug, designated as project number SYHD001, has successfully entered Phase I clinical trials. This important milestone not only signifies substantial progress in the collaboration between the two parties but also serves as a powerful testimony to the cutting-edge technology platform of Sanyou Bio. SYHD001, as an ADC drug, presents extremely high technical demands and development complexities. Sanyou Bio has laid a solid foundation for the successful development of the drug from the outset with its three innovative platforms for biologic drugs: Super-trillion molecule discovery platform, Integrated R&D platform, and Intelligent R&D platform. Sanyou Bio completed the target research, raw material preparation, key molecule generation, assisted and cooperated in completing ADC conjugation and some in vitro and in vivo efficacy experiments, and helped the client to quickly and efficiently screen out compliant, high-expression, high-quality, and highly stable industrial cell lines for the project, thereby ensuring high-quality production and supply of ADC drugs and successfully promoting the project to rapidly complete IND filing and enter Phase I clinical trials. Dr. Guojun LANG, CEO of Sanyou Bio, said "We are extremely honoured to collaborate with such an excellent partner as Huadong Medicine to advance SYHD001 to the clinical stage. In the future development, Sanyou Bio will continue to be committed to technological innovation and constantly enhance the core competitiveness of our own technology platform. We look forward to partnering with more collaborators to jointly promote the development of the biopharmaceutical industry and contribute more to the cause of human health." Since its establishment in 2015, Sanyou Bio has provided systematic solutions from target to IND to accelerate the drug development process through five key categories of innovative biologic drug R&D. The five key R&D stage services include: Target Discovery and Raw Material Preparation, Molecule Generation, Molecule Optimization, Pharmacology and Efficacy Analysis, and Cell line Development and Production Process. To date, Sanyou Bio has served 1,000+ pharmaceutical clients, 7 CPO projects have been obtained IND approval, 10+ projects are in the preclinical R&D stage, 26 collaborative R&D projects are progressing in manner. It has extensive experiences covering 100+ PCC projects and 300+ antibody drug discovery projects, and has cooperated or assisted partners in publishing more than 50 papers, including top journals such as CNS. About Huadong Medicine Huadong Medicine Co., Ltd. (SZ.000963) was founded in 1993, with its headquarters located in Hangzhou, Zhejiang. Adhering to the company value of "Science Driven, Patient Centered", Huadong Medicine has gone through over 20 years of development, and has established a business presence covering the entire pharmaceutical industry chain, with four major business segments: pharmaceutical industry, pharmaceutical commerce, aesthetic medicine, and industrial microorganism, and has grown into a large comprehensive pharmaceutical listed company that integrates pharmaceutical R&D, manufacturing, and distribution. In 2022, Huadong Medicine achieved a revenue of 37.715 billion yuan. With a current employee count exceeding ten thousand, the company possesses extensive commercial coverage and strong marketing capabilities. About Sanyou Bio Sanyou Biopharmaceuticals Co., Ltd. is a world-leading high-tech biotechnology enterprise focusing on R&D and services of innovative biologic drugs. Sanyou has built the 4C business patterns that integrate "differentiated CRO, integrated CDO, innovative CPO and characteristic CRS", to accomplish the mission "to make the R&D easy for innovative biologics". Sanyou has established an integrated innovative biologic drug R&D laboratory with advanced facilities, and has a professional team with the majority holding a Ph.D. or master degree. Sanyou has built three industry-leading innovative technology platforms featured by "super-trillion, integration, and intelligence", which are comprised of more than 50 sub-platforms with the core innovative super-trillion phage display platform, and supported by platforms of material preparation, biologics discovery, molecule optimization, in vitro and in vivo efficacy, production cell line construction, upstream and downstream process development, preclinical R&D, industrialization development, etc. Sanyou's business network has expanded to all parts of the world, including Asia, US and Europe, and established branches in Boston, Philadelphia, San Diego and London. Sanyou has established friendly business relationships with more than 1000 pharmaceutical companies, drug R&D institutions and diagnostics companies worldwide. Sanyou received National-level certification as a high-tech enterprise and a Specialized and Sophisticated enterprise, and passed the ISO9001 quality assurance certification and GB/T intellectual property management system certification.
HO CHI MINH CITY, Vietnam, July 16, 2024 /PRNewswire/ -- On the lively evening of July 13th, Nguyen Hue Pedestrian Street was buzzing with excitement as Kara Soul, sporting a vibrant red SingNow shirt, made a memorable appearance. Kara Soul, the beloved mascot of the online karaoke app SingNow, stole the show. SingNow is currently hosting the "Kara Soul Takes Over Ho Chi Minh City" event, promising not only entertainment but also a chance for participants to mingle, showcase their singing prowess, and snag some fantastic prizes. This marks Kara Soul's debut in Ho Chi Minh City, where fans can finally meet and greet this adorable character in person. From July 10th to July 31st, players can dive into the action by signing up and completing challenges on the SingNow app. The event isn't confined to the digital realm; there are also offline gatherings. So, if you spot Kara Soul on the streets, don't miss the opportunity to interact and earn event points. A special meet-and-greet with Kara Soul is scheduled for July 27th at Vivo City (1058 Nguyen Van Linh Street, Tan Phong Ward, District 7, Ho Chi Minh City). Attendees who complete tasks will receive charming souvenirs from Kara Soul, and those brave enough to perform a song live will pocket instant cash prizes. Additional rewards from the online event, such as Courage Medals, Courage Cars, Courage Jewelry, coins, and beans, will be automatically credited to players' accounts. Plus, lucky winners stand a chance to bag exclusive prizes like the OPPO Reno12 Pro, Xiaomi Watch S3, and Xiaomi Buds4 Pro. With a blend of online excitement and offline fun, "Kara Soul Takes Over Ho Chi Minh City" promises music lovers a summer packed with vibrancy and thrill. Don't wait—head to SingNow now to join in the festivities and grab some fabulous prizes. SingNow is one of the first online karaoke applications launched in Vietnam. As a karaoke app with a unique operating model of "entertainment singing + social community," SingNow always puts users at the center, constantly innovating and bringing young people increasingly exciting entertainment experiences. SingNow will continue to uphold the concept of "Creating an online karaoke entertainment platform for everyone with a musical dream," bringing more surprises and excitement to users.
CAMBRIDGE, Mass., July 15, 2024 /PRNewswire/ -- Nona Biosciences, a global biotechnology company providing a total solution from "Idea to IND" (I to ITM), ranging from target validation and antibody discovery through preclinical research, announced today that it has entered into a collaboration agreement with Alaya.bio, a biotechnology company developing a novel polymeric delivery platform, to precisely target and reprogram cells in situ and thus to significantly simplify the way CAR-T cell therapies in particular are being developed, manufactured and administered. This collaboration aims to leverage Nona's proprietary HCAb Harbour Mice® platform and its newly introduced site-specific conjugation technology, alongside Alaya.bio's polymeric in situ delivery platform, to develop CAR-T product candidates for potential clinical applications. Nona's fully human HCAbs are revolutionizing antibody discovery with their compact size, simplified structure, and precisely calibrated binding properties, making them ideal for next-generation biotherapeutics. Unlike traditional methods that utilize non-specific conjugation technology, Nona's novel site-specific conjugation technology preserves the antibody's binding and function, thereby enhancing the specificity of Alaya.bio's novel polymeric delivery systems while reinforcing the versatility of the platform. Under the first phase of the collaboration, Nona will provide Alaya.bio with access to antibodies against multiple targets as potential targeting moieties for Alaya.bio's in vivo CAR program. In the second phase of the collaboration, Alaya.bio will nominate one or more binders that will be conjugated onto their polymeric nanoparticles in a site-specific manner using Nona's site-specific conjugation technology to advance Alaya.bio's CAR product candidate towards clinics. Dr. Jingsong Wang, Chairman of Nona Biosciences, stated, "We are excited to collaborate with Alaya.bio in advancing CAR-T cell therapy. By combining Nona's industry-leading technology and expertise with Alaya.bio's innovative in situ polymeric delivery platform, we look forward to introducing more promising CAR-T therapies to patients worldwide." Renaud Vaillant, CEO & Co-founder of Alaya.bio, stated, "We are delighted to start this collaboration between Alaya.bio and Nona Biosciences. The quality of the targeting agents that we graft onto our polymeric nanoparticle ensures the efficacy and safety of our technology. With Nona Biosciences, we have identified promising new-generation candidates that clearly differentiate from what exists and from what has been used by others." About Nona Biosciences Nona Biosciences is a global biotechnology company committed to cutting-edge technology innovations and providing a total solution from "Idea to IND" ("I to ITM"), ranging from target validation and antibody discovery through preclinical research. The integrated antibody and antibody-related discovery services with multiple modalities range from antigen preparation, animal immunization, single B cell screening, to antibody lead generation and engineering, developability assessment and pharmacological evaluation, leveraging advantages of Harbour Mice® platforms and the experienced therapeutic antibody discovery team. Harbour Mice® generate fully-human, monoclonal antibodies in classical two light and two heavy chain (H2L2) and heavy chain-only (HCAb) formats. Integrating Harbour Mice® and a single B cell cloning platform, Nona Biosciences is focused on driving global inventions of transformative next-generation drugs. For more information, please visit: www.nonabio.com. About Alaya.bio Alaya.bio is a pioneering biotechnology company dedicated to advancing in situ gene delivery platform, particularly in the field of CAR-T cell immunotherapy. Alaya.bio's proprietary polymeric delivery nanoparticle offers precise targeting of cells and organs, and enhanced delivery of a wide range of therapeutic payloads, from viral vectors to nucleic acids (incl. mRNA). It can be used either ex vivo (as part of rapid manufacturing processes) or in situ (in situ transduction within the patient after systemic administration). To learn more, please visit: https://www.alaya.bio
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