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TREEFROG PRESENTS DATA FROM THEIR PARKINSON'S CELL THERAPY PROGRAM AT THE AMERICAN ACADEMY OF NEUROLOGY ANNUAL MEETING

TreeFrog Therapeutics reports on the first bioproduction of a cell therapy for Parkinson's Disease in a scalable bioreactor1 BORDEAUX, France, April 15, 2024 /PRNewswire/ -- TreeFrog Therapeutics, a cell therapy development company with its lead program in Parkinson's Disease is presenting for the first time at the annual meeting of the American Academy of Neurology, taking place in Denver, Colorado April 13-18, 2024. Parkinson's disease is a complex neurodegenerative disorder that affects more than 10 million worldwide, characterized by the progressive loss of dopamine-producing neurons in the brain. This debilitating condition manifests primarily through a range of motor symptoms such as tremors, rigidity, and bradykinesia, as well as non-motor symptoms which can include cognitive impairment and mood disorders. Symptoms usually appear when between 60%-80% of dopaminergic neurons are already lost, so a regenerative medicine approach that can replace these neurons holds great potential. The poster presentation highlights the unique approach of TreeFrog Therapeutics in developing an off-the-shelf cell therapy with induced pluripotent stem cells (iPSC) using their proprietary technology, C-Stem™, the world's first GMP-compliant encapsulation technology for the amplification and differentiation of cells. In contrast to other PD cell therapy approaches based on the transplantation of single cell suspensions, the C-Stem™ technology combined with standard bioreactors allows for the generation of brain-injectable 3D neural microtissues containing mature dopaminergic neurons. This unique format has the potential to enhance dopaminergic neuron survival post-transplant. "I am excited to represent the Parkinson's Disease team at TreeFrog at our first presentation at the American Academy of Neurology. We have developed a first-in-world technology, C-Stem™ and with this now have the first successful application of the 3D format microtissue that delivers efficacy in pre-clinical models. The results speak for themselves with full behavioral recovery observed by 16 weeks after transplantation using the cryopreserved 3D cell format. We look forward to continuing to bring our data to the scientific community as we advance our program" said Kevin Alessandri, Chief Technology Officer, TreeFrog Therapeutics.   Details of the presentation Title: Off-the-shelf bioreactor produced, iPSC-derived neural microtissues containing dopaminergic neurons innervate the striatum and normalize behavior in a Parkinson Rat Model Primary author: Nicolas Prudon, presented by Kevin Alessandri Date: 15th of April at 11:45am-12:45pm Poster: P4 – Poster session 4; Poster presentation 3-007 www.treefrog.fr 1 Data on file. Poster XXXX, American Academy of Neurology Meeting 13th – 18th April, 2024 ContactRachel MooneyChief Communications OfficerTreeFrog TherapeuticsRachel.mooney@treefrog.fr  

文章來源 : PR Newswire 美通社 發表時間 : 瀏覽次數 : 457 加入收藏 :
Links International Releases The Ultimate 2024 Salary Guide - 4 Sources of Salary Data, 1 Salary Guide!

HONG KONG, April 15, 2024 /PRNewswire/ -- Links International's 2024 Asia Salary Guide brings you detailed insights and trends covering the 2024 job market landscape across Hong Kong, Singapore and Mainland China. Explore evolving job market dynamics in the region to better prepare for the year and to ensure informed decision-making and strategic planning. This year's Salary Guide is no ordinary salary guide. We've revamped our Salary Guide by including 4 sources of salary data to help our clients and candidates access accurate market salaries without having to check multiple salary sources. Key findings from the 2024 Asia Salary Guide include: 1. Winning and Declining Job Roles Hiring is on the horizon in the second half of 2024 and the roles that are particularly high in demand include: Data Scientists AI/Machine Learning Engineers Blockchain Developers Cybersecurity Engineers Full Stack Developers Scientific R&D Roles Sourcing & Procurement Digital Finance HR transformation and Organisation Transformation Job roles that will decline this year include: Traditional Logistics Transactional Accounting Traditional Transactional Corporate Supporting Functions 2. A Job Market Slowdown in 2023 Despite Asia's prime locations remaining vital for investment and job creation, Mainland China, formerly Asia's economic powerhouse, slowed in 2023 due to geopolitical tensions and reduced foreign investment, leading to fewer job opportunities. Neighbouring location, Hong Kong experienced a milder job market decline, with lower unemployment rates despite relaxed visa rules for foreign talent. Tourism recovery bolstered Hong Kong's economy, fostering optimism for sustained growth and job stability. In Southeast Asia, including Singapore, job markets stayed strong in 2023 but didn't reach 2022's peak demand. 3. Talent For High Demand Skillsets Continues To Be Increasingly Difficult to Source in 2024 Employers are finding it extremely difficult to source new talent in certain high demand roles including Data Scientists, AI/Machine Learning, Blockchain, Cybersecurity, Procurement, Digital Finance and Insurance. Accordingly, Governments in Asia have been launching a number of measures to win the battle for these high demand fields with Hong Kong being one of the most aggressive by opening multiple new pathways for work permits and brining talent in from Mainland China. 4. Singapore's HR Landscape Remains Busy and Talent Hungry Singapore, Asia's technology hub is now home to 80 of the world's top 100 tech firms and has set initiatives like the Overseas Networks & Expertise Pass (ONE) and the Tech@SG programme which simplify work visa procedures for international tech talent. Additionally, Singapore aims for 15,000 certified HR professionals to join the workforce by 2027 – the Ministry of Manpower's HR Industry Transformation Plan (HR ITP) focuses on digitalising HR processes, developing strategic capabilities, and adopting progressive practices. 5. Sales & Marketing Bounces Back in Asia Hong Kong's retail sales surged in 2023, with a significant 15.9% increase in November – driving a revival in inbound tourism. This boosted demand for roles in travel retail, sales, customer experience, and management. Singapore is focusing on omnichannel strategies, with 48% of shoppers browsing in physical stores before online purchases and 49% vice versa. Omnichannel spending is expected to reach nearly 62% by 2026. While the China sales and marketing job market remains muted, China's sales and marketing industry is transforming to data-driven, intelligent strategies amidst ongoing digitisation in 2024 and marketing and data related professionals with these skillsets are in high demand. The Ultimate 2024 Salary Guide can be downloaded for free here! About Links International As a leading HR service provider in Asia, Links International is committed to maintaining its position by delivering top-notch payroll services and an unparalleled HR tech experience to clients. With nine consecutive years of being voted Asia's Best HR Outsourcing Partner, our team of over 200 Asia HR Experts offers in-country support from more than 20 locations across the region. We provide expert HR advice tailored to local markets, offering industry best practices and practical solutions to leading businesses in Asia. Website: www.linksinternational.comLinkedIn: www.linkedin.com/company/links-recruitment-limitedFacebook: www.facebook.com/hongkonglinks/X: www.twitter.com/Links_AsiaInstagram: https://www.instagram.com/links_international_hr/

文章來源 : PR Newswire 美通社 發表時間 : 瀏覽次數 : 421 加入收藏 :
ASEAN Foundation Unveils Research Findings on Digital Literacy, Spotlighting the Digital Divide Across the Region

SINGAPORE, April 11, 2024 /PRNewswire/ -- The ASEAN Foundation, with support from Google.org, unveiled research findings on digital literacy at the ASEAN Regional Symposium: Unveiling Insights into the Region's Digital Literacy, held on March 20, 2024, in Bangkok. Titled "One Divide or Many Divides? Underprivileged ASEAN Communities' Meaningful Digital Literacy and Response to Disinformation," the study delves into the digital engagement of underprivileged ASEAN communities. It examines their knowledge, skills, experiences, and responses to disinformation with the aim of establishing a baseline understanding of digital literacy's role in recognizing and responding to disinformation within these communities. This research is one of the flagship programs of the ASEAN Digital Literacy Programme (ASEAN DLP), following the successful empowerment of over 190,000 individuals across ASEAN with essential digital literacy skills. The ASEAN DLP includes direct outreach by the ASEAN Youth Advisory Group, which actively mobilizes the campaign through various social media channels, engaging 3,000 people through onsite activities and reaching over 900,000 on social media. It has also launched an e-learning platform addressing misinformation, www.DigitalClassASEAN.org. "As the latest ASEAN Digital Literacy Programme research concludes, the ASEAN Foundation invites strategic stakeholders to attend and discuss the study reports and findings. This research covered quantitative survey and qualitative data collection from all 10 ASEAN member states. We are presenting it at this symposium so attendees can listen to insights and recommendations from each member country and have in-depth discussions with country researchers. We hope this research will help bridge the digital divide in the ASEAN region and create a more inclusive and safer digital space," said Dr. Piti Srisangnam, Executive Director of ASEAN Foundation.  According to the report, levels of critical thinking and privacy protection competence vary widely across ASEAN member states. Notably, Thailand exhibits the lowest percentage of individuals with high critical thinking skills, at 25%, contrasting with neighboring Cambodia's impressive 62.2%. The Philippines is behind in privacy protection competence, with only 17.42% of individuals possessing high competence, while Singapore excels with 54.37%. Singapore consistently ranks highly in global innovation indices. While Singapore's economic growth has fluctuated over the years, it experienced a significant increase in 2021. However, disparities persist in computer access, particularly among seniors and low-income households, limiting full digital participation. False information online poses a threat to trust and social cohesion, leading to government actions like the POFMA (Protection from Online Falsehoods and Manipulation Act). The research identified several factors contributing to the complexities of digital inequality in Singapore. These include social and cultural factors such as social support networks, access to technology, and cultural attitudes towards technology use. Additionally, psychological factors such as individual motivations, cognitive abilities, and personality traits influence digital engagement. Lastly, material capital, referring to financial resources and their role in facilitating access to and utilization of digital technologies, was also found to be a significant factor. The report underscores the importance of information literacy in the digital era, focusing on critical thinking and source evaluation skills. Suggested strategies to bridge the digital divide include initiatives like the Silver Infocomm Junctions program for seniors, integrating computer science into the school curriculum, and fostering social support networks among communities and families for guidance on digital technologies. Ensuring equitable access to resources, including affordable devices and reliable internet connectivity, remains crucial. Collaborative efforts are necessary to cultivate a more inclusive digital society and address persistent disinformation challenges, with a focus on continuous education and awareness campaigns. With the release of these groundbreaking findings, the ASEAN Foundation aims to spark meaningful discussions and foster collaborative efforts among stakeholders to address the multifaceted digital literacy challenges facing the ASEAN region. Its goal is to strengthen community resilience against mis/disinformation through comprehensive digital literacy programs and stakeholder engagement, taking into consideration infrastructure disparities, socio-cultural influences, and varying government initiatives across ASEAN. As Marija Ralic, Lead for Google.org APAC, said, "We are proud to support the ASEAN Foundation in empowering people across the region with crucial media literacy and online safety skills. Google.org's dedication to fostering digital safety aligns perfectly with the ASEAN Foundation's mission to empower ASEAN communities through digital literacy which will contribute to digitally resilient ASEAN." Previously, Google.org supported the ASEAN Foundation with a $1.5 million grant to aid the implementation of ASEAN DLP from 2022 to 2024. The ASEAN Regional Symposium was also attended by the Chair of the Board of Trustees of the ASEAN Foundation, representatives from Google.org, representatives from the ASEAN Secretariat, local implementing partners of ASEAN DLP, ASEAN entities, think tanks and digital literacy experts in the region. The  symposium concluded with a panel discussion on "From Divide to Empowerment: Strategies for Inclusive Digital Literacy in ASEAN." that discussed empowerment strategies towards inclusive digital literacy, especially among the underprivileged communities in ASEAN. About the ASEAN Foundation Three decades after ASEAN was established, ASEAN leaders recognised that there remained inadequate shared prosperity, ASEAN awareness, and contact among people of ASEAN. It was out of this concern that ASEAN leaders established the ASEAN Foundation during ASEAN's 30th Anniversary Commemorative Summit in Kuala Lumpur, Malaysia on 15 December 1997. The ASEAN Foundation is an organization by and for the people of ASEAN. The Foundation exists because of one vision: to build a cohesive and prosperous ASEAN Community. As an ASEAN body, the Foundation is tasked to support ASEAN mainly in promoting awareness, identity, interaction, and development of the people of ASEAN. For more info about the ASEAN Foundation, visit www.aseanfoundation.org. About Google.org Google.org, Google's philanthropic arm, brings the best of Google to help solve some of humanity's biggest challenges by combining funding, product donations, and technical expertise to support underserved communities and improve opportunities for everyone. It engages nonprofits, social enterprises, and civic entities who make a significant impact on the communities they serve, and whose work has the potential to produce scalable, meaningful change.

文章來源 : PR Newswire 美通社 發表時間 : 瀏覽次數 : 202 加入收藏 :
China continuously expands high-level opening-up

BEIJING, April 15, 2024 /PRNewswire/ -- A report from People's Daily: In the eyes of many foreign companies, investing in China means investing in the future. A survey conducted by the China Council for the Promotion of International Trade showed that over 80 percent of surveyed foreign-invested enterprises rated China's business environment in 2023 as "satisfactory" or above. In the annual China Business Climate Survey released by AmCham China in February this year, half of the 343 members surveyed placed China as their first choice or within their top three investment destinations globally. With a continuously optimized business environment, foreign companies in China can better enjoy the opportunities brought about by the country's high-quality development and high-level opening-up. A sound business environment is crucial to high-level opening-up. At present, China is working to build a market-oriented and world-class business environment governed by a sound legal framework, so as to enhance its ability to attract domestic and international factors of production and resources. The rule of law is the best business environment. Whether foreign companies will face discrimination and unfair treatment when participating in regional development and investing in related projects is a common concern of them. Recently, an action plan aimed to further attract and utilize foreign investment was issued, proposing a series of pragmatic measures to make competition fairer, including improving the bidding system. In recent years, China has enacted and implemented the Foreign Investment Law, made its legal system related to foreign affairs more open and transparent, and strengthened intellectual property right protection. China has worked to improve its institutional framework, promoting higher-level opening-up on the basis of the rule of law. This has created a more stable, fair, transparent and predictable investment environment for foreign companies. A country or region's degree of openness to the outside world and its level of connectivity with the external environment to some extent decide its ability to attract foreign investment and are important parts of its business environment. In 2013, the first edition of China's negative list for foreign investment had 190 items. Currently, the national version of this list has only 31 items, while the version for pilot free trade zones has just 27 items. This contrast highlights China's solid steps towards greater openness to the outside world. The shortening negative list for foreign investment, the exploration of mutual recognition of standards with major trading partners, the high-quality implementation of the Regional Comprehensive Economic Partnership, as well as the efforts made to promote institutional opening-up, achieve high-level alignment with international economic and trade rules, and advance a broader agenda of opening-up across more areas and with greater depth... All these endeavors will open up vast opportunities for the development of foreign companies, bringing new opportunities to the world with China's new development. The real test of how good a business environment is lies in the services provided. When a foreign entrepreneur first arrived in Shanghai, he needed to register and file taxes but could not find multilingual application channels. In January this year, an English version of the International Services Shanghai website went into trial operation, providing not only consulting services for taxation, accounting, etc., but also integrating various information resources. "I can even recommend this website directly to my grandmother when she travels to Shanghai. I no longer have to worry about translating a large amount of information," said the entrepreneur, highlighting the progress in Shanghai's government services and the optimization of China's business environment. Establishing a round-table conference system for foreign-invested enterprises, implementing five measures to facilitate foreigners coming to China, solving mobile payment issues for foreigners in China...These services address practical problems for foreign companies and personnel, and will help fully unleash their innovation vitality. China has become a synonym of the best investment destination, and that the "next China" is still China. In the future, China will take multiple measures and make unremitting efforts to continuously improve its business environment and steadily promote higher-level opening-up. It is believed that the country will continue to be a hot destination for global investment, and make new and greater contributions to global development.

文章來源 : PR Newswire 美通社 發表時間 : 瀏覽次數 : 100 加入收藏 :
HyperStrong Ranked in BNEF Energy Storage Tier 1 List

BEIJING, April 12, 2024 /PRNewswire/ -- BloombergNEF (BNEF), a globally renowned research institute, released its Tier 1 list of energy storage manufacturers for the second quarter of 2024. HyperStrong secures a position on the list, as a testament to the wide recognition of its years of technological expertise, outstanding delivery capabilities, and strong bankability. BNEF has developed a tiering system for battery cell makers and system integrators. Based on bankability as evidenced by deployment, the system is designed to create a transparent differentiation between the hundreds of stationary energy storage manufacturers in the market. This list consists of the energy storage manufacturers meeting the BNEF Tier 1 criteria as of Q2 2024. Speaking on this global recognition, Dr. Jianhui Zhang, CEO of HyperStrong said, "Being recognized as a Tier 1 manufacturer by BloombergNEF not only underscores our years of commitment to quality and innovation, but also reinforces our position at the forefront of the energy storage industry. It is also a significant endorsement of our ability to meet the highest standards of project bankability and operational excellence, as well as a reflection of the trust our customers place in us to deliver best-in-class and reliable energy storage solutions " About HyperStrong Beijing HyperStrong Technology Co., Ltd. ("HyperStrong") is a leading energy storage system integrator and service provider. With over 12 years of R&D and experience garnered through more than 300 projects and over 15GWh of deployment, HyperStrong offers a full portfolio of energy storage products as well as one-stop solutions for clients ranging from thermal power and renewable power generation to C&I and residential users. Having built four smart manufacturing bases, two R&D centers, a testing lab and a global marketing center, HyperStrong empowers clients worldwide to achieve their energy transition and carbon neutrality goals. According to a report unveiled by S&P Global, HyperStrong is ranked one of the top 5 energy storage system integrators worldwide in terms of project scale as of July 2023.  

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【2024 AACR Late Breaking Research】TransThera announces clinical data of tinengotinib to treat patients with advanced solid tumors harboring actionable FGFR1-3 alterations

NANJING, China and GAITHURSBURG, Md., April 12, 2024 /PRNewswire/ -- TransThera Sciences, a clinical-stage biopharmaceutical company focused on inventing differentiated drugs for global patients, announced the poster presentation at the 2024 American Association for Cancer Research (AACR) to discuss the latest breaking research of tinengotinib for patients with advanced solid tumors harboring actionable FGFR1-3 alterations. Monotherapy for patients with advanced solid tumors harboring actionable FGFR1-3 mutations: Fibroblast growth factor receptor (FGFR) alterations occur across various malignancies and are potent oncogenic drivers in multiple tumor types. FGFR inhibitors have demonstrated efficacy in several cancers with FGFR alterations. However, no effective therapies are available worldwide for patients with advanced solid tumors harboring actionable FGFR1-3 mutations currently. Tinengotinib is a unique multi-kinase inhibitor that has very distinct binding mode to FGFR 1-3 proteins, rendering it highly potent to a series of FGFR mutations, including gatekeeper mutations, molecular brake mutations, cystine binding site mutations, and others. This feature has made it highly differentiated from existing FGFR inhibitors, indicating its potential to target cancer patients bearing a broad range of FGFR mutations. The retrospective analysis of the pooled results from four clinical studies of tinengotinib in advanced solid tumors harboring actionable FGFR1-3 mutations showed efficacy in multiple tumor types, including cholangiocarcinoma, breast, prostate, urothelium, colon and head and neck cancer. Our data demonstrate 33.3% BOR and 88.2% DCR, 6.90 months mPFS. The promising results validated the novel mechanism of tinengotinib and clinical applications for potentially FGFR 1-3 altered patients with solid tumors. About tinengotinib Tinengotinib is an innovative, global phase III stage spectrum-selective kinase inhibitor that exerts antitumor effects by targeting tumor cells proliferation, angiogenesis and immune-oncology pathways by inhibiting the cytokine signaling and angiogenesis (FGFRs and VEGFRs), mitotic kinases Aurora A/B and Janus kinases (JAK).  Ongoing clinical trials in the US and China have revealed the potential of tinengotinib to be efficacious in various solid tumors. It was granted the Orphan Drug Designation and Fast Track Designation by the FDA for the treatment of CCA,  the Breakthrough Therapy Designation (BTD) by NMPA in China, the Orphan Drug Designation(ODD) for the treatment of biliary tract cancer by EMA. About TransThera  TransThera Sciences (Nanjing), Inc. is a clinical-stage biopharmaceutical company dedicated to developing innovative therapeutics to target diseases with major unmet medical needs via the internal research platform and open innovation. TransThera's current portfolio covers therapeutic areas such as oncology, inflammatory, and cardiovascular diseases. For more information, please visit www.transthera.com Forward-looking statements This news contains forward-looking statements that involve risks, uncertainties, and assumptions. If risks or uncertainties ever materialize or the assumptions prove incorrect, our actual results may differ from those expressed or implied by such forward-looking statements. All statements other than statements of historical facts could be deemed forward-looking, including, but not limited to, any statement of the plans, strategies, and objectives of management for future operations, including but not limited to our clinical development and commercialization plans; any projections of financial information; any statements about historical results that may suggest trends for our business; any statements of expectation or belief regarding future events, potential markets or market size, technology developments, our product pipeline, clinical data, results or practices or the implications thereof, enforceability of our intellectual property rights, competitive strengths or our position within the industry; and any statements of assumptions underlying any of the items mentioned.

文章來源 : PR Newswire 美通社 發表時間 : 瀏覽次數 : 692 加入收藏 :
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