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Metabolomics-Derived Pathway Scores Outperform Inflammatory Protein Markers—Delivering Risk Prediction Where Proteomics Falls Short MORRISVILLE, N.C., Feb. 17, 2026 /PRNewswire/ -- Metabolon, Inc., the global leader in providing metabolomics solutions advancing a wide variety of life science research, diagnostic, therapeutic development, and precision medicine applications, today announced its industry-leading global metabolomics platform was used by researchers from Kite, a Gilead company, for the most extensive metabolomic study ever conducted in the context of CAR T-cell therapy. Leveraging Metabolon's untargeted Global Discovery Panel, Kite researchers analyzed more than 3,800 longitudinal serum and plasma samples—and a rare set of cerebrospinal fluid (CSF) samples—from patients treated with the FDA-approved anti-CD19 CAR T-cell therapies axicabtagene ciloleucel (axi-cel) and brexucabtagene autoleucel (brexu-cel). The multi-trial meta-cohort, spanning six clinical studies, enabled investigators to uncover metabolic pathways strongly associated with severe neurological events (NEs), a significant and sometimes life-threatening toxicity of CAR T-cell therapy. Despite the transformative efficacy of CAR T-cell treatments for large B-cell lymphoma (LBCL), mantle cell lymphoma, follicular lymphoma, and B-cell acute lymphoblastic leukemia, the biological drivers of neurotoxicity have remained poorly understood. "This study demonstrates how metabolomics uniquely exposes the biological pathways driving CAR T-cell–associated neurotoxicity, insights that are not accessible through proteomics or cytokine profiling alone," said Heino Heyman, Director of Global Field Metabolomics Sciences at Metabolon. "By mapping disruptions in tryptophan catabolism, NMDA-linked excitotoxicity, and polyamine metabolism, the analysis not only identified patients at risk for severe neurologic events but also highlighted actionable pathway targets to mitigate toxicity. These findings demonstrate that metabolomics provides a functional, pathway-level understanding of safety and patient response, which is crucial for enhancing cell therapy design, monitoring strategies, and clinical outcomes." Using Metabolon's high-resolution metabolomics platform, researchers identified clear and reproducible metabolic signatures that distinguished patients who developed high-grade NEs (grade ≥ 3). Notable findings include: Elevated Tryptophan Breakdown Signals Higher Neurotoxicity Risk - Patients who developed severe neurological events consistently showed higher breakdown of tryptophan, leading to increased levels of metabolites, such as quinolinate. These markers were present both before and after treatment and are strongly associated with heightened neurotoxicity risk. Increased Arginine Pathway Activity Reflects Heightened Immune Stress - Severe cases also showed a shift in how the body processes arginine, resulting in the production of more urea and acetylated polyamines, such as N1, N12-diacetylspermine. This pattern reflects increased immune system activation and may serve as another indicator of neurotoxicity risk. CSF Findings Confirm Metabolic Disruption in the Brain - Cerebrospinal fluid samples taken during neurotoxic events showed the same metabolic disruptions observed in blood—higher levels of glutamate and other stress-related metabolites—confirming that these changes directly involve the central nervous system. Metabolite-Based Scores Predict Neurotoxicity Better Than Traditional Markers - New metabolic pathway scores built from these biomarkers outperformed standard inflammatory markers (such as IL-6 and TNFα) in identifying patients at risk for severe neurological events. This demonstrates the potential for more accurate, metabolomics-driven early warning tools. Key Metabolites Also Track with Disease Progression - The same metabolites linked to neurotoxicity—such as quinolinate and acetylated polyamines—were also associated with worse disease outcomes. Machine-learning models reinforced the importance of the tryptophan-kynurenine pathway for neurotoxicity associated with CAR T cell therapy. "These findings underscore the power of metabolomics to reveal mechanisms that are invisible to genomic, proteomic, and cellular assays alone," said Ro Hastie, CEO of Metabolon. "By enabling unprecedented resolution into metabolic dysfunction associated with CAR T-cell therapy, Metabolon's platform has helped identify new biomarkers and potential therapeutic targets to mitigate severe neurotoxicity." To learn more about Metabolon's industry-leading Global Discovery Panel, please visit: https://www.metabolon.com/services/untargeted-metabolomics/global-panel/ About Metabolon Metabolon, Inc. is the global leader in metabolomics, with a mission to deliver biochemical data and insights that expand and accelerate the impact of life sciences research and complement other 'omics' technologies. With 25 years of experience, 15,000+ client projects, 4,000+ scientific publication references, and ISO 9001:2015, CLIA, and CAP certifications, Metabolon has developed industry-leading scientific, technology, and bioinformatics techniques. Metabolon's Global Discovery Panel is powered by the world's largest proprietary metabolomics reference library. Metabolon's industry-leading data and translational science expertise help customers and partners address some of the most challenging and pressing questions in the life sciences, accelerating research and enhancing development success. The company offers scalable, customizable multiomics solutions, including metabolomics and lipidomics, that support customer needs from discovery through clinical trials and product life-cycle management. For more information, please visit www.metabolon.com and follow us on LinkedIn and Twitter. About MetabolomicsMetabolomics, the large-scale study of all small molecules in a biological system, is the only omics technology that provides a complete current-state functional readout of a biological system. Metabolomics enables researchers to see beyond the genetic variation of individuals, capturing the combined impact of genetic and environmental factors, including the effects of drugs, diet, lifestyle, and the microbiome, on human health. By measuring thousands of discrete chemical signals that form biological pathways in the body, metabolomics can reveal important biomarkers, enabling a better understanding of a drug's mechanism of action, pharmacodynamics, and safety profile, as well as individual responses to therapy.
加州聖地亞哥, Feb. 16, 2026 (GLOBE NEWSWIRE) -- Sapu Bioscience 今天公佈在全球知識產權組合方面取得了進展，該組合支援其專利的 TGF-β 反義治療平台 OT-101，強化在神經病學、腫瘤學及中樞神經系統 (CNS) 藥物遞送方面的保障。 OT-101 背景簡介 OT-101（TGF-β 反義抑制劑）是一項臨床階段的治療藥物，先前已在包括膠質母細胞瘤和胰臟癌在內的多種腫瘤領域進行臨床試驗。本公司正致力於將OT-101開發為一種可靶向中樞神經系統的治療平台，並輔以標靶遞送技術和擴展的智慧財產權保護。 柏金遜症 在澳洲，該公司已獲得涵蓋 OT-101 (SEQ ID NO:9) 的專利權利要求，用於治療柏金遜症，當中包括日間過度嗜睡及失眠。該專利申請涵蓋治療方法、藥物製造流程，以及中樞神經系統供藥途徑，當中包括鞘內及顱內灌注。 顱內供藥裝置 在中國及德國，名為「用於顱內持續灌注液體藥劑組合物之遞送裝置」的實用新型專利已獲授出（中國專利編號：CN 222693486 U，自 2025 年 4 月 1 日起生效；德國專利編號：DE 21 2023 000 368.6，有效期直至 2033 年），為持續顱內灌注技術提供裝置層面的保障。 策略性影響 這些知識產權的發展建立了一個綜合的 OT-101 中樞神經系統商業化平台，將治療用途的申請與已獲授出的遞送裝置保障互相結合，藉此提升 OT-101 在研發、合作及商業化方面的策略價值。 管理層評論 行政總裁 Vuong Trieu 博士透露：「這些專利授權標誌著 OT-101 發展的一個關鍵轉捩點。透過取得針對柏金遜症的治療方法申請，以及獲批准的顱內遞送裝置專利，我們已在中樞神經系統策略周圍建立綜合性的知識產權防護體系，將 OT-101 定位成為從分子到遞送裝置皆受到全面保護的平台，為策略性合作及臨床進展作好準備。」 該公司將於 2026 年 3 月 23 日至 25 日在 BIO-Europe Spring 會議上展示 OT-101 及其 Deciparticle™ 領先候選藥物 Sapu003（靜脈注射依維莫司）的相關數據。 關於 OT-101 OT-101 是一種處於臨床階段的 TGF-β 反義抑制劑，在膠質母細胞瘤及胰臟癌方面具有臨床使用或研究歷史，現已進階成為具中樞神經系統遞送能力的治療平台，並有更全面的知識產權保護。 關於 Deciparticle™ 平台 Deciparticle™ 平台是一種專利的納米技術，可將疏水性分子封裝成小於 20 納米的納米粒子作靜脈注射用途，提升全身對藥物的接觸覆蓋，並且於臨床規模實現精準供藥。 關於 Sapu Bioscience Sapu Bioscience 是一間臨床階段的生物技術公司，致力於推進腫瘤學和神經學領域的專利平台，包括 OT-101 和 Deciparticle™ 納米醫學平台，並且擁有符合 ISO-5 cGMP 標準的生產設施。 欲了解更多訊息，請瀏覽 www.sapubio.com。 聯絡資料： Sapu Bioscience：投資者關係ir@sapubio.com
PROVIDENCIALES, Turks and Caicos Islands, Feb. 13, 2026 /PRNewswire/ -- KuCoin, a leading global crypto platform built on trust, today announced the global launch of KuCoin Live and the evolution of KuCoin Feed 2.0—a major upgrade to its content and community layer that connects real-time market conversation with professional-grade execution inside the KuCoin App. Together, the updates are designed to bring market discussion and trading-native tools into one seamless experience, helping users move from insight to action in a purpose-built environment for cryptocurrency and blockchain. The launch marks the next phase of KuCoin Feed's evolution into a sustainable user-generated content (UGC) ecosystem that encourages interaction and swift, informed decisions. It addresses a long-standing industry gap: market intelligence and community discussion often live on one platform, while execution happens elsewhere—creating friction, fragmentation, and delayed decision-making. KuCoin Feed 2.0 and KuCoin Live bring these workflows closer together, building on KuCoin's previously announced KuCoin Feed, an AI-powered, all-in-one crypto intelligence center that consolidates news, market signals, and insights into a single interface to support faster, more informed decisions. KuCoin Feed 2.0 is built on a simple principle: content should lead to action. Designed to encourage interactions and swift, informed decisions rather than passive scrolling, it introduces a more executable social experience through KuCoin Live, where creators and community leaders can host real-time sessions for market analysis, technical analysis, and interactive engagement. Within Feed 2.0, embedded formats such as Trade Cards, help users translate ideas into clear inputs for their own evaluation and execution directly in-app. Additional interactive tools—including polls and tighter integration across trending topics and token related information pages—encourage active participation and higher-quality discussion, creating a continuous content-to-trade loop without leaving the KuCoin App. KuCoin views this release as an important step in advancing how trading platforms can serve users—not only as venues for execution, but as integrated environments where market intelligence, community interaction, and decision-making converge. By shaping an actionable UGC ecosystem, KuCoin aims to elevate the standard for social trading by aligning influence more closely with transparency, skill, and outcomes. To support long-term quality and user safety, the update also includes a robust backend management system featuring AI-assisted monitoring and risk controls, designed to maintain a safe and professional community environment as the ecosystem scales globally. KuCoin Live and KuCoin Feed 2.0 are now available to global users via the KuCoin App. Learn more about KuCoin Feed and KuCoin Live. About KuCoin Founded in 2017, KuCoin is a leading global crypto platform trusted by over 40 million users across 200+ countries and regions. The platform delivers innovative and compliant digital-asset services, offering access to 1,000+ listed tokens, spot and futures trading, institutional wealth management, and a Web3 wallet. Recognized by Forbes and Hurun, KuCoin holds SOC 2 Type II and ISO 27001:2022 certifications, underscoring its commitment to top-tier security. With AUSTRAC registration in Australia and a MiCA license in Austria, KuCoin continues expanding its regulated footprint under CEO BC Wong, building a reliable and trusted digital-asset ecosystem. Learn more: www.kucoin.com
PROVIDENCIALES, Turks and Caicos Islands, Feb. 13, 2026 /PRNewswire/ -- KuCoin, a leading global crypto platform built on trust, today took part in a featured panel at Consensus Hong Kong 2026 titled "Turning Intelligence into Action." Represented by Edwin Wong, Vice President and Head of Risk Control, KuCoin joined industry leaders to discuss how the digital asset sector can strengthen security, enhance customer protection, and move toward operational standards that work across jurisdictions. The panel synthesized diverse perspectives on risk intelligence, featuring Adam, CEO of Inca Digital, and Amanda, Head of Americas of VerifyVASP. Edwin provided the exchange's operational perspective, focusing on the practical execution of security protocols and the harmonization of global compliance. The discussion centered on a primary friction point in the current market: the latency between instantaneous on-chain data and the slower off-chain processes of identity verification and cross-border cooperation. Panelists analyzed the evolving threat landscape, agreeing that the industry must prioritize self-regulation and sophisticated intelligence to preempt increasingly complex risks. A major focus of the debate was customer protection and asset recovery, with experts concluding that while intelligence tools have significantly matured, the industry must now work toward a unified "Code of Conduct" to navigate multi-jurisdictional complexities. Representing the exchange's front-line operations, Edwin shared how user behavior has fundamentally shifted. "Five years ago, users prioritized engine speed and token listings. Today, the fundamental question is platform safety," Edwin noted. "Market data confirms that in volatile environments, capital migrates toward platforms with visible security commitments. Trust is no longer an abstract concept; it is a measurable metric of user retention and market stability." In this environment, KuCoin emphasized that risk management is no longer only a defensive function—it is a foundational driver of sustainable growth and long-term user confidence. To strengthen user protection in practice, KuCoin continues to advance Proof of Reserves (PoR) reporting and has expanded its security and privacy assurance through certifications such as SOC 2 Type II, ISO 27001, ISO 27701, and CCSS. These efforts are reinforced by KuCoin's $2 Billion Trust Project, a long-term commitment to upgrading custody architecture, real-time monitoring, and global compliance capabilities. KuCoin also shared how modern exchanges are applying intelligence to prevention, including AI-assisted modeling designed to detect anomalous behavior earlier and reduce downstream impacts on users, counterparties, and market integrity. Looking ahead, KuCoin underscored the value of an industry-wide, real-time compliance communication layer—one that enables faster coordination while preserving privacy-by-design principles. KuCoin reaffirmed its commitment to advancing trust-first infrastructure and contributing to standards that support a safer, more resilient digital asset ecosystem. About KuCoin Founded in 2017, KuCoin is a leading global crypto platform trusted by over 40 million users across 200+ countries and regions. The platform delivers innovative and compliant digital-asset services, offering access to 1,000+ listed tokens, spot and futures trading, institutional wealth management, and a Web3 wallet. Recognized by Forbes and Hurun, KuCoin holds SOC 2 Type II and ISO 27001:2022 certifications, underscoring its commitment to top-tier security. With AUSTRAC registration in Australia and a MiCA license in Austria, KuCoin continues expanding its regulated footprint under CEO BC Wong, building a reliable and trusted digital-asset ecosystem. Learn more: www.kucoin.com
特克斯和凱科斯群島普羅維登西亞萊斯島2026年2月13日 /美通社/ -- KuCoin，全球領先的加密貨幣平台，參與了在香港Consensus 2026 的主題論壇「Turning Intelligence into Action」。由 KuCoin 風險控制負責人、副總裁 Edwin Wong 代表出席，KuCoin 與多位行業領袖共同探討數字資產行業如何強化安全能力、提升用戶保護，並推動可跨司法轄區落地的運營標準。 論壇匯聚多元視角，包括 Inca Digital CEO Adam，以及 VerifyVASP 美洲区负责人 Amanda。Edwin 從交易平台一線運營角度出發，分享如何將安全流程落到實際執行，並推動全球合規要求下更一致的協同機制。 論壇重點聚焦於當前市場的一項核心摩擦：鏈上數據幾乎實時，但鏈下流程（如身份驗證與跨境協作）仍相對滯後。與會嘉賓分析了不斷演進的風險態勢，並一致認為行業需要優先推進自律機制與更成熟的風險情報能力，以提前應對日益複雜的風險。討論亦延伸至用戶保護與資產追索，嘉賓指出，儘管情報工具已顯著成熟，但行業仍需推動形成統一的「行為準則」，以更有效地應對多司法轄區下的複雜性。 代表平台一線運營觀點，Edwin 分享了用戶行為的根本變化：「五年前，用戶更看重撮合速度和上幣數量；今天，最核心的問題是平台是否安全。」他指出：「市場數據表明，在波動加劇的環境下，資金會遷移到那些能夠清晰展現安全承諾的平台。信任不再是抽象概念，而是可以體現在用戶留存與市場穩定性上的可衡量指標。」在此背景下，KuCoin 強調風險管理已不再只是防禦性職能，而是支撐可持續增長與長期用戶信心的基礎驅動力。 為在實踐層面進一步強化用戶保護，KuCoin 持續推進儲備證明（PoR）披露，並通過 SOC 2 Type II、ISO 27001、ISO 27701 及 CCSS 等認證體系，提升安全與隱私保障能力。這些舉措也由 KuCoin 的「20 億美元信任計劃（$2 Billion Trust Project）」提供長期支撐，聚焦於升級托管架構、強化實時監測，並擴大全球合規能力。KuCoin 同時分享了行業如何將情報用於「預防」，包括運用 AI 輔助建模更早識別異常行為，降低對用戶、交易對手與市場秩序的連帶影響。 展望未來，KuCoin 強調建立行業級、實時的合規溝通機制的重要性，以在堅持「隱私優先設計」原則的同時，實現更快速的跨機構協同。KuCoin 重申將持續推進「信任優先」基礎設施建設，並為推動更安全、更具韌性的全球數字資產生態貢獻力量。 關於KuCoin 成立於 2017 年，KuCoin 是領先的全球加密資產平台，深受遍佈200多個國家與地區、超過 4,000 萬名用戶信賴。平台提供創新且合規的數字資產服務，涵蓋超過1,000種已上架代幣，並支持現貨及期貨交易、機構級財富管理，以及 Web3 錢包等產品與服務。 KuCoin獲《福布斯》（Forbes）及胡潤（Hurun）認可，並已取得 SOC 2 Type II 及 ISO 27001:2022 認證，彰顯其對高標準安全保障的承諾。在澳洲完成AUSTRAC註冊，並在奧地利取得歐盟《加密資產市場監管條例》（MiCA）框架下的牌照後，KuCoin 在CEO BC Wong的帶領下，持續擴大其受監管業務版圖，致力建構更可靠、值得信賴的數字資產生態。 了解更多：www.kucoin.com
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