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Skyhawk presents today on its novel SKY-0515 small molecule RNA splicing modulator targeting Huntington's Disease to members of the Huntington's Disease Youth Organization, at the annual HYDO International Congress in Prague, Czech Republic. BOSTON, March 15, 2025 /PRNewswire/ -- Skyhawk Therapeutics, Inc., a clinical-stage biotechnology company developing novel small molecule therapies designed to modulate critical RNA targets, today presents on its novel SKY-0515 small molecule RNA splicing modulator targeting Huntington's Disease to members of the Huntington's Disease Youth Organization (HDYO), at the biannual HYDO International Congress in Prague, Czech Republic. SKY-0515 is Skyhawk's investigational small molecule RNA splicing modifier developed through the company's novel RNA-splicing platform. SKY-0515 is designed to reduce both HTT protein and PMS1 protein, an additional key driver of somatic CAG repeat expansion and HD pathology. "We are excited to present on our Huntingtin-lowering clinical trials at the HDYO International Congress this month," said Sergey Paushkin, Chief Scientific Officer and Head of R&D at Skyhawk, "with positive results including SKY-0515's average HTT mRNA reduction of 72% at a daily oral dose of 9mg in trials thus far, and the drug's predicted suppression of the PMS1 protein, SKY-0515, if approved, could make a meaningful difference in Huntington's patients' lives." Huntington's disease is a rare hereditary neurodegenerative disease affecting over 40,000 patients in the United States and many more worldwide. There are no approved treatments that can reverse or slow its course of progression. "We are pleased with the speed at which we've conducted our studies thus far and are focused on this patient community in great need", said Bill Haney, Chief Executive Officer at Skyhawk. "SKY-0515's compelling results thus far demonstrate the immense potential of our platform to target indications for which there are no approved disease modifying therapies." About Skyhawk TherapeuticsSkyhawk Therapeutics is a clinical-stage biotechnology company focused on the discovery and development of novel small molecule therapies designed to modulate critical RNA targets and revolutionize patient treatment for some of the world's most intractable diseases. Skyhawk's discovery expertise is rooted in its proprietary drug discovery platform, which assesses, identifies, and tests RNA splicing targets and small molecules across a broad range of therapeutic areas and disease states. Skyhawk has built collaborations with multiple pharma partners that leverage Skyhawk's novel platform across disease areas including neurodegenerative disease, autoimmune disease, and oncology. For more information visit www.skyhawktx.com. Skyhawk ContactMaura McCarthymaura@skyhawktx.com
BARCELONA, Spain, March 4, 2025 /PRNewswire/ -- Huawei Global Digital Power Summit was held at MWC 2025 with the theme of "AI Powering a Greener ICT." Operators, leading enterprises, industry leaders, and industry experts from around the world attended the event to share their cutting-edge viewpoints and insights, exploring new development opportunities in the era of All Intelligence. Charles Yang, Senior Vice President of Huawei and President of Global Marketing, Sales and Services, Huawei Digital Power At the event, Charles Yang, Senior Vice President of Huawei and President of Global Marketing, Sales and Services, Huawei Digital Power, stressed that the world has made significant achievements in carbon emissions reduction over the past few years, but the climate crisis remains a major challenge for humankind. The total carbon emissions of the telecom industry are about 600 million tons, accounting for 2% of the global total. In the journey to carbon neutrality, telecom operators are facing three major challenges: increased emissions, high energy consumption, and rising energy costs. Huawei Digital Power integrates digital and power electronics technologies to provide all-scenario low-carbon solutions, helping them transform from energy consumers to energy producers and enablers. According to Charles Yang, a number of mainstream operators around the world have not only saved energy and reduced carbon emissions, but also cut their energy OPEX with the help of Huawei. They also participated in the electricity market through virtual power plants (VPPs) to gain extra benefits and find the "second curve" of business growth. In Pakistan, Huawei provided a PV plus energy storage system (ESS) solution to help customers replace gensets with PV power systems, reducing the fuel consumption per site by 96%. The green transformation of 1000 sites is expected to cut the energy OPEX by 38%. In the Czech Republic, Huawei helps operators extend the backup time and increase revenue by participating electricity market based on the same site ESS. In Finland, Huawei has helped a telecom operator aggregate ESSs at telecom sites and in residential, commercial, and industrial scenarios to participate in frequency response services in the electricity market, significantly boosting the revenue. In China's Inner Mongolia, Huawei proposed its subsystem decoupling solution to upgrade an AI data center, helping the customer roll out large language model services rapidly. According to Charles Yang, Huawei Digital Power has helped customers in the ICT industry generate 2.28 billion kWh of green power and save 81.6 billion kWh of electricity, equivalent to reducing carbon emissions by 39.86 million tons and planting 54.46 million trees. ITU and Huawei jointly released White Paper on Lithium Batteries for Telecom Sites At the summit, the International Telecommunication Union (ITU) and Huawei jointly released White Paper on Lithium Batteries for Telecom Sites*, the first of its kind in the world. The white paper advocates the use of "high-quality lithium batteries", requires that batteries offer excellent performance parameters, and emphasizes the importance of end-to-end safety system construction. The white paper also analyzes the safety issues of lithium batteries in telecom sites, shares the global latest research results and best practices in lithium battery safety, and provides guidelines for promoting the safe, reliable, and efficient application of lithium batteries in the communications industry. Reyna úbeda, Engineer to ITU-T SG5: Environment, EMF, Climate Action and Circular Economy, stated that, the standardization sector of the International Telecommunication Union is developing standards to enable environmental efficiency in the ICT sector. High-quality and Safe Lithium Batteries are important to enable more efficient energy storage and usage in telecom sites, thereby reducing the overall carbon footprint of ICT operations. The Data Center Lithium-ion Battery Safety Application White Paper was also released to promote the standardized and large-scale application of lithium-ion batteries in the data center industry. A new age of All Intelligence is coming fast, with AI applications and numerous intelligent scenarios presenting new opportunities and challenges in energy consumption, while creating a great development prospect for the global ICT industry. Huawei Digital Power will continuously invest in innovation and work with global like-minded partners to create new business value and build a better, greener future. * Please download the white paper here: https://www.itu.int/en/ITU-T/studygroups/2025-2028/05/Documents/Reports/2025-03-WhitePaper-LithiumBatteries-TelecomSites.pdf
Global Shipment of TCL Mini LED TV Surges Almost 200% YoY HONG KONG, Feb. 3, 2025 /PRNewswire/ -- TCL Electronics Holdings Limited ("TCL Electronics" or the "Company", 01070.HK) is pleased to announce its global shipment data of TCL TV for 2024. Benefiting from the successful implementation of the Company's "TCL + Falcon" dual brand and "mid-to-high-end + large-screen" strategies, as well as continuous innovation of Mini LED display technology to reinforce its competitive edge, global shipment of TCL TV experienced a year-on-year ("YoY") growth of 14.8% in 2024, reaching a new record high of 29 million sets. Among which, the global shipment of TCL TV increased by 19.3% YoY and 20.0% quarter-on-quarter ("QoQ") respectively in the fourth quarter of 2024, demonstrating robust growth momentum. "Mid-to-High-End + Large-Screen" Trend Continues, Mini LED TV Shipment Further Accelerates, Fully Embracing Intelligent AI Throughout 2024, TCL Electronics continuously capitalised on the global market trends of larger screen sizes and premium features, maintaining double-digit growth in the shipment of large-screen TV. The global shipment of 65-inch and above TCL TV increased by 21.3% YoY, with its corresponding proportion rising by 1.4 percentage points to 26.0%. The global shipment of 75-inch and above TCL TV saw an even more impressive YoY increase of 39.8%, with its shipment proportion rising by 2.4 percentage points to 13.2%. The average screen size of global shipment of TCL TV increased by 1.3 inches YoY to 52.4 inches. Simultaneously, TCL Electronics continued to invest in research and development of high-end display and AI intelligent technologies, further enhancing product competitiveness and introducing well-received mid-to-high-end display products. In 2024, the global shipment of TCL QLED TV increased by 69.5% YoY, while the global shipment of TCL Mini LED TV saw a remarkable 194.5% YoY growth. At the Consumer Electronics Show (CES) 2025, TCL Electronics showcased its continuous breakthroughs in display technologies, introducing the X11K QD-Mini LED TV for the North American market, representing the "pinnacle of image quality". This TV model utilises the world's leading QD-Mini LED technology, featuring an impressive 14,000-level local dimming zones and a peak brightness of 6,500 nits. Combined with TCL's All-domain Halo Control Technology, industry-leading self-developed lenses, high-efficiency light-emitting chips, ultra-close OD, backlight response algorithms, and a 7,000:1 ultra-high native contrast ratio screen, the X11K elevates Mini LED display to new heights within the industry. The TCL X11K TV also received the CES 2025 "Mini LED Display Technology Innovation Award". In addition, the Company unveiled the world's first modular AI home companion robot, TCL Ai Me, at CES 2025. This AI robot features an adorable bionic appearance design with interchangeable outfits and a mobile space capsule base, tailored specifically for modern families. Ai Me possesses multimodal natural interaction capabilities, providing emotional companionship and personified interactions, while being capable of moving intelligently and automatically capturing beautiful family moments. Through continuous interaction with users, Ai Me is able to learn and adapt to family members' behavioural habits, intelligently control home appliances, and enhance the convenience and comfort of daily life, providing a personalised interactive experience for each family member. This innovation was highly appreciated by the vast majority of exhibition visitors. At the same time, the Company further deepened its cooperation with Google, integrating Google's AI large-language model, Gemini, into its overseas flagship television series, significantly enhancing product functionality and user experience. Gemini's powerful natural language processing capabilities enable more intelligent and smooth voice interactions when integrated with TVs. Moreover, Gemini can perform in-depth analysis and precise matching based on each family member's unique viewing habits and interests, providing users with highly personalised program recommendations. The introduction of Gemini offers users a more intelligent and convenient product experience. Shipment in International Market Maintains Leading Position, Mini LED Shipment in Domestic Market Exceeds Expectations In 2024, amid major sporting events such as the European Cup and the Olympic Games, TCL Electronics, through precise marketing in the global market, achieved a YoY increase of 17.6% in TCL TV shipment in the international market. The shipment of large-screen TV in the international market also grew rapidly, with 65-inch and above TCL TV increasing by 32.4% YoY, and 75-inch and above TCL TV increasing significantly by 79.7%. Regionally, benefiting from increased channel penetration, shipment of TCL-branded TV in the European market maintained rapid growth, with a YoY increase of 33.8% in 2024. The shipment of 75-inch and above TCL TV performed particularly well, with a significant YoY increase of 104.9%. Meanwhile, TCL TV ranked second in retail sales volume in France, Poland, and Sweden, and third in Spain, Greece, and the Czech Republic[1]. In North America, the Company effectively enhanced its brand competitiveness through localised brand communication, such as partnering with the National Football League (NFL), while actively adjusting channel and product structure. In 2024, shipment of TCL TV in North America increased by 6.4% YoY, among which 75-inch and above TCL TV increasing by 67.6% YoY, maintaining a top-two position in market share in terms of retail sales volume in the United States[2]. In emerging markets, shipment of TCL TV increased by 12.7% YoY in 2024, with an even higher YoY increase of 32.8% in the fourth quarter. The Company further deepened its presence in the Latin American market and expanded channels in the Middle East and Africa market, with shipment of TCL TV increasing by 17.6% and 39.6% YoY, respectively, in 2024. TCL TV maintained the industry's top position in retail sales volume in Australia, the Philippines, Myanmar, and Pakistan, jumped to second in Brazil, and ranked third in Argentina, Vietnam, Thailand, and South Korea[1]. In the domestic market, the Company continued to promote its "TCL + Falcon" dual brand strategy. In 2024, TCL TV shipment in the PRC market increased by 5.8% YoY, with Falcon brand TV continuing to penetrate the youth market, achieving a YoY growth rate of 38.5% in shipment. TCL Electronics also successfully promoted the "mid-to-high-end + large screen" strategy in the PRC market. Benefiting from the stimulation of the national "trade-in" subsidy policy, the average screen size of TCL TV shipment in the PRC market reached 63.3 inches in 2024, representing an increase of 1.9 inches YoY. The shipment of 75-inch and above TCL TV increased by 23.1% YoY, with the proportion of shipment increasing by 5.3 percentage points to 37.7%. Moreover, in 2024, the shipment of TCL Mini LED TV in the PRC market increased by 264.7% YoY, with the cumulative shipment share of TCL Mini LED TV increasing by 10.9 percentage points YoY to 15.3%, and the shipment share of TCL Mini LED TV in the fourth quarter of 2024 significantly increasing to 24.4%. In 2024, the Company ranked first in retail sales volume of Mini LED TV in the PRC market[3]. Looking ahead, TCL Electronics will continue to execute its "Globalisation" and "Technological Transformation" strategies, adhering to the development strategy of "Lead with Brand Value, Excel in Global Efficiency, Drive with Technology, Thrive on Global Vitality", and the concept of innovation-driven development. With comprehensive technological breakthroughs and user-friendly design, the Company will continuously promote the development trend of smart living, bringing more convenient, comfortable, and environmentally friendly living experiences to global users. By actively implementing the all-category layout of "Intelligent IoT Ecosystem", the Company strives to become a leading smart device enterprise with global operations. Shipment Data for the Year of 2024 (unaudited) Unit: Set Large-sized display – Shipment of TCL TV 29,003,243 - Proportion of TCL TV of 65 inches and above by shipment 26.0 % - Proportion of TCL TV of 75 inches and above by shipment 13.2 % [1] Data Source: GfK, January to November, 2024. [2] Data Source: Circana, January to November, 2024. [3] Data Source: CMM omni-channel, January to December, 2024. About TCL Electronics TCL Electronics Holdings Limited (01070.HK, incorporated in the Cayman Islands with limited liability) was listed on the mainboard of the Hong Kong Stock Exchange in November 1999. It is engaged in display business, innovative business and internet business. TCL Electronics actively transforms and innovates under the strategy of "Lead with Brand Value, Excel in Global Efficiency, Drive with Technology, Thrive on Global Vitality". Focusing on the mid-to-high-end markets around the world, the Company strives to consolidate the "Intelligent IoT Ecosystem" strategy and is committed to providing users with an all-scenario smart and healthy life while developing into a world-leading smart technology company. TCL Electronics is part of the Shenzhen-Hong Kong Stock Connect program and is included in the Hang Seng Stock Connect Hong Kong Index, the Hang Seng Composite MidCap & SmallCap Index and the Hang Seng Corporate Sustainability Benchmark Index. Besides, it has received Hang Seng Index's ESG rating of A for consecutive years since 2018. For more information, please visit the investor relations web page of TCL Electronics at http://electronics.tcl.com or follow the WeChat Official Page of TCL Electronics investor relations.
BEIJING, Jan. 27, 2025 /PRNewswire/ -- A news report from China.org.cn on Spring Festival: How do the Chinese celebrate the Spring Festival? If your knowledge is limited to "eating dumplings", "hanging spring couplets" or "receiving red envelopes," you may want to watch on.  Happy Spring Festival! Here are all the ways you can celebrate! The Spring Festival is the most significant traditional festivity in China, while also being a prominent cultural symbol for China's 56 ethnic groups. When people celebrate the Spring Festival, bidding farewell to the old and saying hello to the new, vivid characteristics of their ethnic groups are often showcased in their celebrations. But if we trace these customs to their original inspirations, we can see that many of them bear similar significance. For example, during the Spring Festival, people of many ethnic groups will choose to eat a specific food, which reflects their wishes for the coming year. The She and Miao people, to start with, will make ciba, a Chinese-style cake made from glutinous rice, as a wish that the year ahead will be just as sweet and pleasant as the dessert's flavor. And there's also the fish. Like the Han people, fish is also a must-have dish for numerous households of Dong and Manchu ethnic groups, since "fish" shares the same pronunciation as the word for "surplus," symbolizing good wishes for a year of wealth. The customs of many ethnic groups also reflect common worship and respect for nature. For example, people of multiple ethnic groups including Bouyei and Nu, regard the first bucket of water they fetch after the new year rings in to be pure and auspicious; for the Zhuang ethnic group, people usually keep a "new year's fire" burning throughout the night; while for some Yi people who live in Yunnan province, pine is worshipped, with local inhabitants putting up pine branches in their yards and laying pine leaves on the floor, to pray for tranquillity, harmony and auspiciousness. At the time of the Spring Festival, not only do families get together, but people of various ethnic groups also engage in all kinds of entertainment, including singing and dancing, competitions of various forms, etc. In recent years, many regions where multiple ethnic groups inhabit have begun to host more inclusive celebrations, as well as shows where performers from different ethnic groups can present their customs to a larger audience. The unique cultures and traditions of the 56 ethnic groups, have pooled more recognition and aroused more resonance through the common bond of the Spring Festival. Last month, the Spring Festival was inscribed on the Representative List of the Intangible Cultural Heritage of Humanity by UNESCO, another milestone after it became a UN holiday in 2023. Although the festival originated in China, it has gone global and has almost immersed itself in the social and cultural fabrics of many countries. Countries like Vietnam and South Korea have listed the Spring Festival as a public holiday, and Panama has announced it to be a national holiday. For quite some years, famous landmarks have put on their "special costumes" for the Spring Festival with festive vibes being very tangible across many cities outside China. For many friends from other countries, the Spring Festival is no longer a vague term, but has been concretized via themes like the customs and the Chinese zodiac animals. What's more, in the Spring Festival celebration events, we saw Hungarian folk dance and traditional Chinese dance performing on the same stage; Czech folk songs were played by musicians from both China and the Czech Republic in a Spring Festival concert in Prague… Thanks to the Spring Festival, the world gets to know China better, and vice versa. With the festival as a conduit, cultures and civilizations are seeing beyond "differences", and realizing more exchanges and integration. After all these examples, it's not hard to see how the Spring Festival spells "diverse" in its DNA. Such diversity strikes a perfect balance with the unity and solidarity shown by China's ethnic groups, as well as with the harmony and inclusiveness of Chinese culture in the kaleidoscope of global civilizations. Happy Spring Festival! May you enjoy a year of harmony and prosperity, happiness and peace! China Mosaichttp://www.china.org.cn/video/node_7230027.htmHappy Spring Festival! Here are all the ways you can celebrate!http://www.china.org.cn/video/2025-01/26/content_117687265.htm
- Addressing Needs of Aging Population and Reducing Workload, Aiming for Expansion in Southeast Asian Markets - TOKYO, Jan. 27, 2025 /PRNewswire/ -- Innophys Co., Ltd. (hereinafter referred to as "Innophys"), a venture originating from Tokyo University of Science, located in Hachioji City, Tokyo, started sales in Singapore of its Muscle Suit (R) powered exoskeleton series on January 6. Image1:https://cdn.kyodonewsprwire.jp/prwfile/release/M106291/202501223205/_prw_PI1fl_V3mwXd0T.jpg Innophys launched the lightweight model "Muscle Suit Soft-Power EASY-LIFT" in October last year. The company is progressing with its market expansion, tailoring its offerings to meet local needs. Following its foray into Romania last year, Innophys has begun selling its Muscle Suit (R) in Singapore as part of its efforts to strengthen its presence in overseas markets. Singapore boasts a high economic standard and is proactive in enhancing labor conditions, adopting advanced technologies. Additionally, as an important logistics hub, Singapore has seen rising interest in the Muscle Suit (R) series for tasks such as cargo handling in factories and warehouses, as well as in the healthcare and caregiving sectors. The country faces a growing need to address the aging population and reduce labor burdens. Through the Muscle Suit (R) model, Innophys aims to improve worker safety and productivity. Singapore is positioned as a hub for the Southeast Asian market. By leveraging the country as a base, Innophys is committed to further expanding into additional overseas markets. The current overseas Muscle Suit (R) distributors are located in the following countries/regions (as January 27, 2025): - Asia: Mainland China, South Korea, Taiwan region, Hong Kong SAR & Macau SAR, Malaysia, Thailand, Singapore - EU: France, Spain, Italy, Germany, Poland, Denmark, Estonia, Latvia, Lithuania, Romania, Czech Republic, Slovakia, Slovenia - Latin America: Mexico Official global websites of Muscle Suit (R):Muscle Suit: https://innophys.net/musclesuit/Information on oversea distributors: https://innophys.net/musclesuit/distributors-and-retailers/ About Muscle Suit Soft-Power EASY-LIFT Image2:https://cdn.kyodonewsprwire.jp/prwfile/release/M106291/202501223205/_prw_PI2fl_72dluVqM.jpg Released on October 21, 2024, this entry-level model is designed for tasks like farming, construction, and transport, reducing lower back strain by 33%. Weighing only 310g, it is lightweight, flexible, easy to wear, washable, and affordable, making it highly practical for users.
SEATTLE, Jan. 18, 2025 /PRNewswire/ -- Perfect Sweat, a seven-part docuseries exploring the rebirth of ancient sweat bathing traditions around the world, is now available on demand. The hit series that has sparked a revival in bathing and wellness culture across the globe follows sweat bathing guru and author Mikkel Aaland as he retraces his steps from his 70s classic, Sweat, to discover the resurgence of these ancient rituals. From Finland to Burning Man — sauna rafts, mobile saunas, and cold plunges, to Aufguss performances in large group saunas — Aaland joins local guides in eight countries, exploring diverse cultures and traditions, showcasing the profound impact of community sweat bathing on the human spirit. "My vision is to see bathhouses on every corner instead of a bar, or a Starbucks," says Aaland in an interview at the Bathhouse - Banya London. Perfect Sweat features a diverse cast of local guides and hosts, including sauna master Miki Tokairin and actor/dancer Sho Ikushima of Japan and sauna expert Lasse Eriksen of Norway. The series episode, Burning Man is directed by Emmy Award-nominated and Grammy award-winning filmmaker Doug Pray and other talented directors from around the globe. The series premiered on June 8th, 2024 - Global Wellness Day and National Sauna Day to a global audience, with viewers tuning in from over 50 countries and has aired on broadcast networks in Finland, Greece, the Czech Republic, and Romania. About the Seven Episodes: Finland: In Finland, saunas are everywhere, and no steam is left unexplored with guide Samuel Aarnio. Mikkel and Samuel island hop by boat, visit old friends for a traditional smoke sauna, and test their limits in 60+ saunas at the Mobile Sauna Festival in Teuva. (Directed by Mika Hotakainen) Aufguss: Experience the art of Aufguss, where sauna meets performance. Mikkel dives into the competitive world of Aufguss with Christine Rose, witnessing elaborate rituals, mesmerizing music, and the power of aromatherapy. (Directed by Wolfgang Ettlich) Russia: Journey through Russia with Anna Artemieva, exploring the social and spiritual heart of the banya. From traditional village banyas to modern urban bathhouses, Mikkel uncovers the deep-rooted traditions and camaraderie of this communal steam bath. (Directed by Sasha Kulak and Alina Rudnitskaya) Japan: Immerse yourself in the serene world of Japanese bathing culture with hosts Sho Ikushima and Miki Tokairin. Mikkel explores ancient onsen and sento rituals, from steaming volcanic hot springs to traditional public bathhouses, where cleansing and relaxation intertwine with nature. (Directed by Kaoru Ima and Michiko Zentoh) Turkey: Step into the opulent world of the Turkish hammam with Elizabet Kurumlu. Mikkel experiences the elaborate cleansing and rejuvenation rituals of this ancient tradition, visiting historical bathhouses and uncovering the secrets of this luxurious bathing culture. (Directed by Tuba Guvelioglu) Norway: Embrace the revitalizing power of the Norwegian sauna with Lasse Eriksen. Mikkel explores the connection between sauna and the outdoors, from breathtaking fjord-side saunas to traditional farm saunas, discovering the health benefits and social customs of this invigorating practice. (Directed by Robin Hansen-Tangen) Burning Man: Explore the unique sweat lodge culture of Burning Man with Zack Robertson and Teresa Yung. As a first-time "burner," Mikkel discovers a vibrant sweat bathing community where self-expression and communal healing converge in the Nevada desert. (Directed by Doug Pray) Perfect Sweat is available to stream now on Amazon Prime Video, Apple TV, Google Play, and YouTube in the English-Speaking territories of the US, UK, Canada, and Australia, and with bonus content worldwide through the film festival interface, Eventive. Website: https://www.perfectsweatseries.com/ Social Media: https://www.facebook.com/PerfectSweatSeries/ https://www.instagram.com/perfectsweatseries/ https://x.com/theperfectsweat About Bray's Run Productions: Bray's Run Productions is an award-winning, Seattle-based independent film production company that specializes in exploring culture, history, and travel through the prism of charismatic people across the globe. We open doors into aspects of culture that traditional media has overlooked. Video - https://www.youtube.com/watch?v=DEW0uj6wmaILogo - https://mma.prnasia.com/media2/2600344/Brays_Run_Productions_Logo.jpg?p=medium600
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