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上海2025年10月14日 /美通社/ -- 雲頂新耀（HKEX 1952.HK）是一家專注於創新藥研發、臨床開發、製造和商業化的生物製藥公司，今日宣佈其通用現貨型腫瘤治療性疫苗EVM14注射液（以下稱為「EVM14」）的全球多中心I期臨床試驗在美國臨床研究機構NEXT Oncology Virginia成功入組首例患者。這是繼EVM14新藥臨床試驗申請（IND）在美國食品藥品監督管理局（FDA）和中國國家藥品監督管理局（NMPA）均獲批准後的一項重要臨床進展。 EVM14基於雲頂新耀自主知識產權的mRNA技術平台研發，是一款靶向5個腫瘤相關抗原（TAA）的通用現貨型腫瘤治療性疫苗，擬用於治療多種鱗狀細胞癌，包括非小細胞肺鱗癌（sq-NSCLC）和頭頸部鱗狀細胞癌（HNSCC）。在EVM14 I期臨床試驗探索的瘤種中，大多數患者會表達5個TAA之一。其中，約96%的sq-NSCLC患者和97%的HNSCC患者檢測到至少一個TAA基因的表達[1]。 雲頂新耀首席執行官羅永慶表示：「EVM14首例患者在美國的成功入組，體現了雲頂新耀mRNA平台從技術創新到全球化臨床開發的重要進展，也展現出公司在腫瘤治療性疫苗等新一代腫瘤免疫藥物研發方面的先行優勢。鱗癌患者群體龐大，現有標準治療難以形成持久免疫記憶，仍未實現令人滿意的治療效果，存在巨大的未滿足醫療需求。作為腫瘤相關抗原疫苗，EVM14不僅可成為現有療法的有力補充，還可能減少復發，有望幫助患者實現『長期無癌生存』的獲益。隨著EVM14的IND獲中國NMPA批准，我們期待該創新療法將在全球多中心臨床上展現積極的治療潛力，為全球患者帶來更多治療選擇，提高患者生活質量。」 在EVM14全球多中心I期臨床試驗中，參與的臨床中心包括美國的NEXT Oncology Virginia、德州大學安德森癌症中心、紀念斯隆-凱特琳癌症中心和中國的上海胸科醫院等。 臨床前試驗結果表明，EVM14在小鼠中誘導了劑量依賴性的抗原特異性免疫應答，並在多個小鼠同源腫瘤模型中顯著地抑制了腫瘤生長。同時，EVM14能夠誘導免疫記憶，展現出有效降低腫瘤復發的能力，有望幫助患者實現「長期無癌生存」的獲益。此外，研究還證明了EVM14與免疫檢查點抑制劑（ICI，如抗PD-1或抗CTLA-4抗體）的聯用可以顯著增強抗腫瘤活性，支持在臨床上對聯合用藥的探索。 關於EVM14 EVM14注射液（也稱為EVM14）是一種不含防腐劑的無菌mRNA-脂質納米顆粒（mRNA-LNP）通用現貨型腫瘤治療性疫苗，由編碼5個腫瘤相關抗原（TAA）的mRNA原液包封在脂質系統中配製而成。肌肉注射後，EVM14可被抗原呈遞細胞（APC）攝取並翻譯成靶抗原，經加工後由主要組織相容性復合體（MHC）分子呈遞，啟動並激活抗原特異性T細胞。這些活化的T細胞可遷移至腫瘤組織，識別並殺死表達靶抗原的腫瘤細胞。 關於雲頂新耀 雲頂新耀是一家專注於創新藥和疫苗研發、臨床開發、製造和商業化的生物製藥公司，致力於滿足亞洲市場尚未滿足的醫療需求。雲頂新耀的管理團隊在中國及全球領先製藥企業從事過高質量研發、臨床開發、藥政事務、化學製造與控制（CMC）、業務發展和商業化運營，擁有深厚的專長和豐富的經驗。雲頂新耀已打造多款疾病首創或者同類最佳的藥物組合，公司的治療領域包括腎科疾病、感染性和傳染性疾病、自身免疫性疾病。有關更多信息，請訪問公司網站：www.everestmedicines.com。 前瞻性聲明 本新聞稿所發佈的信息中可能會包含某些前瞻性表述，乃基於本公司或管理層在做出表述時對公司業務運營情況及財務狀況的現有看法、相信、和現有預期，可能會使用「將」、「預期」、「預測」、「期望」、「打算」、「計劃」、「相信」、「預估」、「確信」 及其他類似詞語進行表述。這些前瞻性表述並非對未來業績的保證，會受到風險、不確定性及其他因素的影響，有些乃超出本公司的控制範圍，難以預計。因此，受我們的業務、競爭環境、政治、經濟、法律和社會情況的未來變化及發展等各種因素及假設的影響，實際結果可能會與前瞻性表述所含資料有較大差別。本公司及各附屬公司、各位董事、管理人員、顧問及代理未曾且概不承擔更新該稿件所載前瞻性表述以反映在本新聞稿發佈日後最新信息、未來項目或情形的任何義務，除非法律要求。 參考文獻: The Cancer Genome Atlas (TCGA) data
SYDNEY, Oct. 14, 2025 /PRNewswire/ -- Meshed Group successfully hosted the inaugural Meshed Innovation Day in Sydney, bringing together over 80 leaders and technologists from the vocational and higher education sector to explore transnational education, global pathways, and innovation. Meshed Innovation Day The program featured keynote addresses, product showcases, and partner spotlights, giving attendees practical insights and strategies for 2025–2026. Key Highlights: A panel on transnational education and global pathways with Dr James Hart (IHEA), Prof. Peter Ryan (Consult Ed), and Pramesh Khadka (Meshed Group). Moby Siddique (RedPandas) delivered a keynote on how institutions are leveraging CRMs integrated with Student Management Systems to boost enrolments and retention. Meshed Group experts shared sessions on admissions optimisation, workforce transformation, and scalable delivery, featuring Adekunle Adedoyin, Raj Rayamajhi, and a joint session by Anthony Rice (PeoplePartners) with Pramesh Khadka. Stan Fan (AWS) and Resha Adhikari (Meshed Group) showcased AI applications in education management and student engagement. Adam Brimo and Trevor Furness (OpenLearning Limited) demonstrated how generative AI is transforming course creation and delivery. A major milestone was the official launch of the Meshed Admissions Platform (MAP) — a purpose-built solution for vocational and higher education institutions to streamline admissions workflows, manage global agent networks, and deliver offers with speed, precision, and compliance. "MAP is more than an admissions tool — it's a growth engine for vocational and higher education institutions. Today's launch shows how ready the sector is for smarter, compliant, and connected admissions," said Pramesh Khadka, CEO of Meshed Group. About Meshed Innovation Day Meshed Innovation Day is Sydney's leading EduTech innovation gathering, hosted annually by Meshed Group. The 2025 theme, "Transnational Education & Global Pathways", focused on preparing institutions for growth, compliance, and digital transformation. About Meshed Group Meshed Group is a leading provider of education technology solutions for higher education, vocational training, and transnational providers. Its portfolio includes Meshed HigherEd, Meshed RTOManager, and the newly launched Meshed Admissions Platform (MAP), enabling institutions to deliver excellence in student management, compliance, and global growth.
AUCKLAND, New Zealand, Oct. 14, 2025 /PRNewswire/ -- Rewardpay.co.nz, the leading B2B fintech platform transforming how businesses pay suppliers and get rewarded, today announced a market-first: integrated tax pooling payments that reward businesses – a breakthrough in how tax pooling is managed. For the first time, businesses can make provisional tax payments directly to their preferred tax pooling provider through the RewardPay platform — earning valuable rewards while streamlining one of their largest financial obligations. This secure, seamless solution currently supports American Express payments, with additional payment options coming soon. Key Benefits for NZ Businesses: Earn rewards for paying tax: Earn American Express Membership Rewards® Points — and optionally, Air New Zealand Airpoints — on every tax pooling payment. Up to 55 days interest-free: Improve cash flow by leveraging extended credit terms through your American Express card. Tax pooling made easy: Enjoy streamlined access to leading tax pooling providers via embedded integrations within the RewardPay platform. "By connecting tax pooling payments directly to the RewardPay platform, we're making it faster, more secure, and — for the first time — rewarding. We're proud to partner with the industry leader TMNZ to bring this to market", said Mark Dawes, CEO of RewardPay. Matt Edwards, CEO of TMNZ, added: "As tax pooling pioneers, we're thrilled to partner with RewardPay to reimagine how businesses manage their tax obligations. This integration removes payment friction, enabling our clients to make provisional tax payments seamlessly using Amex — while also earning valuable rewards. It's a win for efficiency, flexibility, and financial performance." About RewardPay RewardPay is a leading B2B fintech platform transforming business payments into opportunities to earn rewards, enhance cash flow, and streamline operations. For over nine years, RewardPay has partnered with trusted global brands including American Express and Air New Zealand, and now New Zealand's top tax pooling providers to help businesses unlock value from everyday payments. www.rewardpay.co.nz About TMNZ TMNZ (Tax Management New Zealand) is the country's original and leading tax pooling provider, trusted by thousands of businesses and accountants for over 20 years. TMNZ empowers businesses to manage provisional tax with flexibility, reduce interest costs, and gain greater financial certainty. TMNZ is New Zealand's first registered tax pooling intermediary, known for its compliance expertise, innovation, and unwavering support of Kiwi businesses. RewardPay Media Contact:Chloe DawesHead of Marketing & Communicationchloe@rewardpay.com.au
HO CHI MINH CITY, Vietnam, Oct. 14, 2025 /PRNewswire/ -- Dewan Architects + Engineers has been appointed as the Lead Architect and Interior Design consultant for Maia Ho Tram, a landmark hospitality and residential development on Vietnam's southern coastline. Commissioned by Lodgis Hospitality Holdings in partnership with VinaLiving, the project will introduce a new era of wellness-oriented design to The Grand Ho Tram Strip, one of the region's largest integrated resorts. Maia Ho Tram is a landmark hospitality and residential development on Vietnam’s southern coast, designed by Dewan. Situated two hours from Ho Chi Minh City, Maia Ho Tram forms part of Zone A1 of Phase 3 of the resort's master plan. Dewan's design integrates a high-density hospitality and residential programme with a wellness-led ethos, capitalising on the site's oceanfront positioning while creating a strong sense of connection to its natural surroundings. A Vision for Wellness and Coastal Living Dewan's design narrative is centred on wellness and nature-driven principles. A cascading sequence of landscaped terraces and pools links the elevated podium to the beach, while a dramatic axial view connects the grand lobby to the sea. The development spans approximately 103,000 square metres, comprising two high-rise towers—Peace and Happy—a villa cluster, and a vibrant podium of shared amenities. The Peace Tower interiors are inspired by the "golden forest" concept, evoking the soft light filtering through trees at sunset. Villas arranged around a natural pond, podium-level leisure and dining options, and a rooftop wellness deck reinforce the development's focus on healthy, contemporary living. "Maia Ho Tram is a milestone project that reflects the values we bring to every commission: sustainability, lifestyle-driven design, and architectural innovation," said Ammar Al Assam, CEO of Dewan Architects + Engineers. "Vietnam and Southeast Asia are rapidly growing markets, and we are proud to contribute with a project that sets new benchmarks for wellness and hospitality, while creating long-term value for both residents and guests." Adding to this, Freek Jansen, Branch Manager of Dewan Southeast Asia, commented: "Our vision for Maia Ho Tram is to design more than just buildings—we are shaping an experience that brings people closer to nature while delivering the highest standards of contemporary living. It is a unique opportunity to strengthen our presence in Vietnam and demonstrate how design-led thinking can define new models of resort living." Integrated Lifestyle Experience The project includes a hotel operated by Fusion Hotel Group under the Maia Resort brand, 1,244 condominium apartments, and 36 low-rise villas. The podium will feature a seafood restaurant, two-level food court, kids' club, golf simulator, wellness centre, multifunctional hall for 400 people, and a beach club. The rooftop podium deck extends the resort lifestyle skyward with a lap pool, landscaped terraces, and fitness amenities. Two towers rising 31 and 32 floors are strategically oriented for panoramic views of the ocean, their skyline softened by terraced pocket gardens. Extensive glazing, vertical fins, and shading devices ensure efficiency and elegance in the tropical climate. Dewan will also oversee the implementation of Building Information Modeling (BIM), ensuring coordination across disciplines and precision in project delivery. Groundbreaking took place in April 2025, with construction now underway. Completion is scheduled for Q3 2027. About Dewan Architects + Engineers For over 40 years, Dewan Architects + Engineers has been at the forefront of the architecture and engineering industry in the Middle East, Asia, and beyond. Renowned for delivering innovative, sustainable, and people-centred designs, Dewan's portfolio spans hospitality, residential, commercial, education, and mixed-use sectors. With a multidisciplinary team and a commitment to design excellence, Dewan continues to shape transformative projects that redefine urban and cultural landscapes. For high-resolution photos, please download the media kit here. Maia Ho Tram is a landmark hospitality and residential development on Vietnam’s southern coast, designed by Dewan. Maia Ho Tram is a landmark hospitality and residential development on Vietnam’s southern coast, designed by Dewan.
Founded and led from Asia, the new platform is established to help close the region's USD 815 billion annual climate finance gap. As a mission-driven, non-profit initiative, the Advisory will channel all its resources toward deepening regional insight, expanding partnerships, and increasing Asia's capacity for strategic climate giving. The Advisory will mobilise millions in catalytic philanthropic capital and unlock larger flows of public and private finance into Asia's climate solutions. SINGAPORE, Oct. 14, 2025 /PRNewswire/ -- The Asia Climate Philanthropy Advisory – the first regional platform dedicated to climate giving, founded and led from Asia – was launched at a reception officiated by Guest-of-Honour Mr Ravi Menon, Ambassador for Climate Action, Singapore. The occasion highlighted the leadership role Asia must play in closing the climate finance gap and accelerating solutions. As a mission-driven, non-profit initiative, the Advisory will channel all its resources toward deepening regional insight, expanding partnerships, and strengthening Asia's capacity for strategic climate giving. By addressing barriers such as complexity, gaps in collaboration, and a lack of tailored knowledge, it will help make climate philanthropy in the region more effective and impactful. In doing so, the Advisory will mobilise millions in catalytic philanthropic capital from Asia and unlock far larger flows of public and private finance into regional climate solutions. "Asia is critical to the world's climate future but faces a large gap in climate finance. Innovative partnerships and trusted networks involving philanthropic capital as a complement to public and private finance will be key to closing this gap. Singapore remains committed to support Asia's transition, and I am heartened that new collaborative initiatives are taking root here to help channel philanthropic resources towards impactful climate solutions in Asia," said Ambassador Ravi Menon. If we are to avert catastrophic climate impacts in Asia, the region must unlock new forms of capital – including philanthropy – to supplement public and private finance. Asia is at the heart of the global climate challenge. The region faces an USD 815 billion annual finance gap, with decisions in the next decade set to determine global outcomes. Yet while Asia drives nearly two-thirds of global wealth creation, its philanthropists contribute only 12% of global climate philanthropy. With over 80% of ultra-high-net-worth giving already staying within the region, there is significant potential for catalytic, risk-tolerant capital to accelerate Asia's transition. "Our mission is to make climate giving in Asia simpler, more strategic, and more impactful," said Laura Lee, the Advisory's newly appointed CEO. "By pairing trusted knowledge with regional context and networks, we aim to empower Asian philanthropists to act decisively and shape a sustainable future for the region." The initiative is backed by Tara Climate Foundation, Children's Investment Fund Foundation, Asia Philanthropy Circle, Growald Climate Fund, High Tide Foundation, Sequoia Climate Foundation, among other philanthropies. It builds on nearly two years of scoping and consultations with philanthropists, intermediaries, non-profit organisations and networks across Asia. "Asia's climate future is the world's climate future," said Jamie Choi, CEO of Tara Climate Foundation. "This Advisory is a bold, Asia-first step to close the gap – a trusted platform that equips philanthropists from across Asia with the confidence and connections to fund solutions rooted in the region's realities." Sonia Medina, Executive Director for Climate at CIFF, added: "Philanthropy can play a unique role in tackling the climate crisis – by seeding innovation and supporting systemic change. With Asia's centrality to global outcomes, this Advisory provides the trusted guidance and networks philanthropists need to step forward with confidence." "Addressing the climate challenge will require a collective effort, especially in Asia where we have the opportunity to step up more," said Laurence Lien, Chairman of Asia Philanthropy Circle. "This Advisory reflects the spirit of collaboration that is essential to unlock the giving potential in Asia, and to help Asian philanthropists to give more, give now and give well." About the Asia Climate Philanthropy Advisory (ACPA) The Asia Climate Philanthropy Advisory (ACPA) is the first regional platform for climate giving, founded and led from Asia. ACPA provides philanthropies in the region with trusted guidance, regional insight, and partnerships to help mobilise catalytic capital for the region's climate transition. As a mission-driven, non-profit initiative, it works to strengthen Asia's capacity for strategic climate giving and unlock greater flows of public and private finance toward climate solutions.
Recognising Roboyo, WNS, Deloitte, Accenture, and Via Appia for delivering process excellence SYDNEY, Oct. 14, 2025 /PRNewswire/ -- Appian (Nasdaq: APPN) has today announced the recipients of its 2025 Asia-Pacific and Japan (APJ) Partner Awards, recognising excellence across five different categories. The awards honour high-performing partners who have driven significant growth in customer engagements and delivered transformational value through the Appian Platform. This year's recipients have built world-class solutions and services spanning multiple industries, reinforcing another successful year for Appian's partner ecosystem in the region. "We're proud to recognise our partners and the vital role they play in driving business transformation throughout APJ," said Steve Gillett, Regional Vice President, APJ Alliances at Appian. "These Partner Awards showcase the remarkable impact our partners deliver for organisations across the region through their own deep expertise and commitment. Each of these partners has demonstrated exceptional dedication in providing outstanding value to the customers we serve together." The APJ Partner Awards program honours strategic partners who demonstrate leadership in enabling transformation with Appian. The winners have expanded Appian's market presence while establishing new standards for delivering impactful solutions. This year's winners were announced at Appian's Partner Celebration Event in Sydney. Delivery Award Winner: Roboyo Roboyo has demonstrated outstanding achievement in delivering Appian projects with quality, speed, and measurable customer impact. The firm has delivered digital transformation across government, insurance, and higher education sectors in Australia, modernising critical processes including incident management, compliance, invoice automation, case collaboration, HR, finance, and student services. Roboyo has introduced first-of-its-kind innovations such as generative AI automation, cross-agency collaboration portals, and WCAG-compliant student platforms. These initiatives have resulted in reduced manual effort, improved compliance, faster turnaround times, and stronger transparency. Innovation Award Winner: WNS WNS has distinguished itself as an innovation leader through the development of Life Support Outage Management (LSOM) with PowerAlert, a unique solution addressing critical challenges faced by energy and utilities providers. These organisations often face compliance risks and operational inefficiencies due to manual outage management processes, creating safety concerns for vulnerable customers. WNS developed an integrated solution featuring real-time dashboards, automated outage notifications, accurate asset-to-customer mapping, and enforced compliance protocols. The solution achieved full compliance with outage notification requirements, eliminated regulatory breaches, and reduced manual workload significantly while improving operational productivity. Most importantly, it enhanced safety and service delivery for critical customer groups. Growth Award Winner: Deloitte Deloitte has shown exceptional commitment to accelerating Appian's growth through a multi-year investment in its alliance with Appian. Building momentum with a strong pipeline and expanded delivery capability through practitioner enablement, Deloitte has secured early new customer wins with expansion opportunities already underway. With dedicated alliance leadership within Deloitte's Engineering division, the practice has achieved rapid expansion with broad enablement across practitioners. Deloitte's strategic focus on Public Sector and Financial Services, supported by executive sponsorship and proof-of-concept initiatives, has driven strong momentum across industries and geographies throughout Australia. Transformation Award Winner: Accenture Accenture has been an exceptional leader in driving transformational change through large-scale enterprise transformation with the Appian Platform. The firm is supporting post-merger integration and digital transformation for a large superannuation provider, unifying legacy systems and streamlining processes across the organisation. Accenture's approach consolidates technology platforms and simplifies operations for efficiency and reduced complexity while enhancing member experience through digital channels, personalised interactions, and data-driven insights. The initiative has delivered measurable customer value including improved member satisfaction, simplified operations, and cost efficiencies. Using a phased approach with initial focus on integration followed by digital and operational enhancements, the transformation continues to expand to support future mergers and enterprise-wide change. Channel Partner of the Year Award Winner: Via Appia Via Appia has shown its dedication to expanding Appian's presence across the APJ region through significant investment across multiple categories, including innovation, Appian Practice development, and delivery. The firm has expanded its presence in the Philippines with new customer wins in banking and government, delivering digital check deposit solutions for a leading bank and mission-critical automation for national institutions. By leveraging the Appian Platform, Via Appia has improved transparency, compliance, and customer experience for clients. As a longstanding regional practice with deep expertise and proven delivery success, Via Appia has demonstrated measurable customer value, from faster transactions to streamlined business processes. About Appian Appian is The Process Company. We deliver a software platform that helps organizations run better processes that reduce costs, improve customer experiences, and gain a strategic edge. Committed to client success, we serve many of the world's largest companies across various industries. For more information, visit appian.com. [Nasdaq: APPN] Follow Appian: LinkedIn, X (Twitter) Logo - https://mma.prnasia.com/media2/1488235/Appian_Caption_2700px_Logo.jpg?p=medium600
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