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SHENZHEN, China, Nov. 4, 2025 /PRNewswire/ -- ONERugged offers a full range of intrinsically safe rugged tablets and smartphones — including the EM-I17J (EX), T1, and P1 — purpose-built for the oil & gas, chemical, and mining industries. Certified to ATEX standards, these explosion-proof rugged devices deliver reliable performance for mobile workers, enhancing productivity and ensuring safe operations in hazardous environments. Explosion-Proof Rugged Devices Are Your Mobile Devices Safe Enough for Hazardous Areas? In industries where safety and reliability are non-negotiable, mobile devices must withstand the harshest and most unpredictable environments. ONERugged's intrinsically safe rugged tablets and smartphones are engineered to operate confidently in explosive atmospheres, providing frontline workers with secure, real-time access to data and communication tools without compromising safety. Combining rugged durability with intelligent performance, these ATEX-certified devices help organizations in oil & gas, chemical, and mining sectors improve operational efficiency while maintaining the highest safety standards on site. Certified for Safety: Explosion-Proof + Rugged Design Every ONERugged intrinsically safe rugged device is rigorously engineered and tested to meet international explosion-proof and safety standards. Certified to ATEX requirements, the EM-I17J (EX), T1, and P1 are approved for use in Zone 2/22 hazardous environments, where explosive gases or dust may be present. Their specialized structural design, reinforced sealing, and anti-static materials prevent ignition sources, ensuring safe operation even in volatile conditions. Beyond explosion-proof protection, ONERugged devices also meet MIL-STD-810H and IP65/IP68 durability standards, providing resistance against shock, vibration, dust, and water ingress. This robust construction allows the tablets and phones to perform reliably under extreme temperatures, heavy industrial use, and demanding field conditions — keeping mobile workers connected and productive wherever safety matters most. Delivering Triple-Layer Protection for Frontline Operations Motherboard Circuit Protection:The explosion-proof rugged devices' high-reliability components with overcurrent, overvoltage, and short-circuit protection prevent electrical faults that could cause sparks or explosions, ensuring safety in complex industrial environments. Current-Limiting Control:Precisely regulates current, voltage, and power to prevent ignition energy generation, maintaining safe parameters during prolonged operation in hazardous areas such as petrochemical or mining sites. Battery Smart Charge–Discharge Management:The explosion-proof rugged devices feature an intelligent battery management system that continuously monitors charging and discharging, preventing overcharge and over-discharge to reduce failure and safety risks. Thermal & Pressure Protection:Automatically disconnects from the motherboard when internal temperature or pressure exceeds safety limits, preventing battery overheating or explosion. High-Density Coated Separator:Offers excellent insulation, heat resistance, and temperature stability, ensuring reliable battery performance in extreme environments. Casing Rugged & Reliable Protection:Certified to MIL-STD-810H and IP65 standards for dustproof, waterproof, and drop resistance, the explosion-proof rugged devices ensure stable operation and device integrity in harsh field conditions. Electrostatic Discharge (ESD) Protection:Withstands ±8kV contact and ±15kV air discharge to eliminate electrostatic ignition risks in hazardous areas. Anti-Vibration Design:Shock-absorbing housing minimizes vibration and impact on internal components, maintaining stability and operational safety during field use and transport. Empowering Field Productivity in Hazardous Environments The ONERugged EM-I17J (EX) explosion-proof rugged tablet delivers reliable industrial performance with an Intel N5100 processor, Windows 11/10 OS, 8GB RAM, and 128GB storage. Its 10.1-inch HD/high-brightness display is sunlight-readable, and the 8MP rear/5MP front cameras support photo capturing. Practical features include 2D barcode scanning, NFC, 4G, GPS/Glonass, multiple ports, and a 7.6V/5000mAh removable battery for long working hours. As for the ONERugged T1 outdoor rugged explosion-proof tablet, it provides smooth performance with the Helio G99 chip, Android 14 OS, 8GB RAM, and 128GB ROM. Its 8.68-inch HD display with Incell technology delivers vivid visuals, while the Samsung 48MP rear camera and 32MP front camera help field operators capture clear pictures from afar. It also features Wi-Fi 5, 4G, Bluetooth 5.1, precise navigation, and an 8000mAh battery with 33W fast charging. Meanwhile, the ONERugged IP68 outdoor rugged explosion-proof smartphone P1 offers high performance with the Helio G99 platform, Android 14 OS, 8GB RAM, and 128/256GB storage. Its 6.56-inch display supports wet-hand and glove touch, while the 48MP quad-camera handles field documentation needs. Additional features include a 5800mAh battery, 1.5W speaker, 4G/public network walkie-talkie, NFC, and multi-mode positioning, making it a reliable companion for outdoor industrial operations. Proven Reliability Across Industries ONERugged intrinsically safe rugged devices have been widely adopted across oil & gas, chemical, and mining operations, where reliable mobile solutions are essential for maintaining both safety and productivity. In the oil & gas sector, explosion-proof rugged tablets and phones are used for on-site inspections, pipeline monitoring, and maintenance logging, helping engineers collect and transmit data without entering hazardous zones. In chemical plants, the devices support digital workflows for quality control, asset tracking, and safety compliance, reducing paperwork while maintaining accurate records. In the mining industry, workers rely on these rugged devices for communication and equipment diagnostics in high-dust, vibration-prone environments, ensuring reliable performance both underground and on the surface. For emergency rescue and the energy sector, these devices can secure the fire scene command and maintenance work in flammable or high-voltage areas. Driving Safety and Innovation Forward As industries continue to embrace digital transformation, ONERugged remains committed to advancing operational safety and mobility in hazardous environments. With intrinsically safe, ATEX-certified rugged tablets and smartphones, we deliver the reliability, performance, and protection that frontline workers need to operate with confidence. Engineered to perform where ordinary devices cannot, ONERugged's explosion-proof solutions enable safer, smarter, and more connected industrial operations. To learn more about ONERugged's intrinsically safe tablets and smartphones, visit ONERugged's website www.onerugged.com and Emdoor Information's website www.emdoorrugged.com. Note: ONERugged is a brand of Emdoor Information Co., Ltd. (SZSE: 001314). EM-I17J (EX) is from Emdoor Information, P1 and T1 are from ONERugged. About ONERugged ONERugged is a leading provider of rugged computing solutions for enterprise users worldwide. Focused on durability, performance, and versatility, ONERugged designs products that can withstand the harshest environments and deliver reliable performance across a wide range of industries, including rugged tablets, rugged notebooks, rugged handhelds, vehicle PCs, industrial panel PCs, and outdoor rugged series. Today, ONERugged serves clients in over 100 countries and regions, supporting sectors such as public safety, manufacturing, agriculture, automotive, and warehousing logistics. For more information, visit www.onerugged.com. Follow us on LinkedIn, YouTube, and Facebook.
MADRID, Nov. 3, 2025 /PRNewswire/ -- Technical experts, industry leaders, and Huawei's partners from around the world met at the 10th Huawei Connect Europe event in Madrid to explore how AI and other technologies are accelerating Europe's digital and green transitions under the event theme of "All Intelligence, Greener Europe". "The intelligent world is approaching faster than we ever imagined," said David Wang, Huawei's Executive Director of the Board. "AI, 5G, and green energy will change education, healthcare, finance, manufacturing, and every other industry. Such technologies will create countless opportunities for growth by transforming business logic, service models, and entire value chains. In just five years, AI alone will contribute US$22.3 trillion to the global economy." David Wang, Huawei's Executive Director of the Board, delivers a speech at Huawei Connect Europe Wang said the next decade will be critical to Europe's twin transition, and that during that time, Huawei's commitment to remain "in Europe, for Europe" will remain strong. Supported by a network of R&D centers, innovation labs, manufacturing bases, and supply chain hubs, Huawei is driving innovation and localization to help its European customers go digital and green. Together with its partners in Europe, Huawei is determined to turn this shared vision into an opportunity, and this opportunity into lasting growth – for an all intelligent and greener Europe. - Embracing a more intelligent and sustainable Europe together Leo Chen, Huawei's Senior Vice President and President of Enterprise Sales, delivers a keynote at the event "We are committed to supporting the continent's digital and intelligent transformation through investment in technological innovation, partner ecosystems, and talent development," said Leo Chen, Huawei's Senior Vice President and President of Enterprise Sales. "Together, we can build a more intelligent and sustainable Europe." In terms of technological innovation, Chen said Huawei has launched flagship products and solutions in Europe to help enterprises build their own digital infrastructure. It has also launched the HUAWEI eKit 4+10+N SME Intelligence Solutions, which focus on four scenarios: intelligent office, intelligent business, intelligent education, and intelligent healthcare. These solutions make it easier for SMEs to adopt new technology and power the last mile of the intelligent world. Regarding partner ecosystems, Huawei has announced SHAPE 2.0 for enhanced collaboration with local partners in Europe. SHAPE 2.0 is an upgraded version of the SHAPE partnership framework that was released by the company last year. Huawei also released the partner alliance development plan to enable its distribution partners to better provide scenario-based solutions and services for their customers. In talent development, Huawei has worked with both universities and partners to cultivate talent and create value for local communities through Huawei ICT Academies, joint labs, and certification programs. This event brought together guests from various organizations who shared their perspectives on strategies for Europe's digital and green transitions. These guests included Matías González Martín, Secretary General of Telecommunications and Regulation of Audiovisual Communication Services at the Ministry for Digital Transformation and Public Service, Government of Spain; Ultan Mulligan, CSO of ETSI; Armin de Greiff, CIO of University Hospital Essen; Sebastiaan Moesman, Chief Strategy Officer of Azerion; Pablo Pirles, General Manager of Iberdrola | bp pulse; Francisco Pérez Spiess, CTO & Co. Founder of Wattkraft Solar GmbH; and Jing Fang, Chief Expert of the UNESCO Regional Bureau for Science and Culture in Europe. For more details, please visit the official website of HUAWEI CONNECT 2025 • MADRID. https://www.huawei.com/eu/events/huaweiconnect-madrid
The popular food and travel guide unveils a comprehensive list of 18,000 restaurants New "Hometown" cuisine theme focuses on local flavours abroad Top culinary shifts include sustainability, experiential dining and vegetarian options MACAO, Nov. 3, 2025 /PRNewswire/ -- Trip.Gourmet, the leading food and travel guide under Trip.com Group, has unveiled its 2026 Global Restaurant Selection List at its flagship event, the Trip.Gourmet Global Restaurant Rankings and Dining Awards Ceremony, held at The Londoner Macao. This year's theme, "New Coordinates for Taste", celebrates the world's top restaurants across 68 countries, spotlighting over 18,000 dining destinations. The list, compiled from a blend of user reviews and expert insights, showcases the finest establishments in each category. The announcement comes amid the growing trend of culinary tourism. According to Trip.com Group data, food-related searches have seen a 30% year-on-year increase globally. Sunny Sun, Vice President of Trip.com Group and CEO of Trip.Gourmet, shared, "Today's travellers are no longer just eating their way through destinations, they're using cuisine as a compass. The list reflects this shift by offering not only rankings but also cultural connection, storytelling, and curated discovery." A New Blueprint for Culinary Discovery A major strategic upgrade of the platform was announced, reflecting the changing dynamics of global food tourism and travellers' evolving dining preferences. The ranking list has been streamlined from its original four thematic categories (Fine Dining, Local Restaurants, Light Bites, and Views & Experiences) into three targeted themes: Fine Dining: Featuring the prestigious Black Diamond, Diamond, and Platinum tiers. Must-Visit Restaurants: Integrating the best of local gems, unique experiences, and casual bites. Hometown Cuisines: A brand-new category designed to help overseas travellers and expatriates find familiar flavours that evoke a sense of home. Currently available in Mainland China, Japan, South Korea, and Southeast Asia (Singapore, Malaysia, Thailand, Vietnam, Indonesia, Philippines, Myanmar, Laos, Brunei, Cambodia), the Hometown Cuisines list features regional categories such as Japanese Cuisine, Korean Cuisine, and Southeast Asian Cuisine. Personalised by user location, the list helps travellers find regional dishes in global cities. For example, Korean users in Shanghai can now discover top-rated Korean restaurants in the city. This is based on insights that nearly half of outbound tourists have stated they will actively seek out restaurants offering their hometown's speciality dishes. Restaurant List Highlights and Key Trends The latest rankings highlight the best dining experiences across major culinary cities worldwide, including Hong Kong, Shanghai, Beijing, Macao, Singapore, Copenhagen, Paris, Dubai, Bangkok and Tokyo. Renowned high-end restaurants, such as Plénitude (France), SÉZANNE (Japan), La Pergola (Italy), Odette (Singapore), and Caprice (Hong Kong), dominate the Fine Dining – Black Diamond category. Many of these top-tier establishments are also affiliated with prestigious luxury hotels, including Four Seasons, The Ritz-Carlton, Shangri-La, and Mandarin Oriental, ensuring a premium all-in-one dining experience. Other key culinary trends include: Sustainability: Many top restaurants are adopting environmentally conscious practices such as zero-waste cooking and farm-to-table sourcing. Examples include Narisawa (Japan) and Vanderlyle (United Kingdom), renowned for their focus on local, seasonal ingredients. Fusion Cuisine: Sola in Paris blends Japanese techniques with French influences, while Potong in Bangkok fuses Thai-Chinese flavours, showcasing the rise of fusion dining. Vegetarian & Plant-Based Dining: With plant-based dining gaining momentum, high-end restaurants like Lamdre (Beijing) and Cookies Cream (Berlin) are making haute cuisine more accessible to vegetarian and vegan diners. Contemporary & Molecular Gastronomy: In Europe, Alchemist (Copenhagen) and Noma (Denmark) are leading the charge, while Junsik (Seoul), Ling Long (Shanghai) and Labyrinth (Singapore) are making waves in Asia. Japanese Flair: Japan's sushi mastery shines at Sushi Harasho (Osaka), while Matsukawa (Tokyo) epitomises refined kaiseki dining. A Celebration of Chinese Cuisine: A significant portion of high-end Chinese restaurants make the list, showcasing regional specialities, including新荣记 (Xīnróngjì) and龙景轩 (Lóngjǐng Xuān). Immersive dining: Unique dining experiences like Le Petit Chef (Kuala Lumpur), underwater Ocean Restaurant (Singapore) and Elisa Floating Restaurant in Vietnam, prove that atmosphere plays a key role in dining. View the full list here. New Features and Experiences for Fork-First Travel Trip.Gourmet continues to elevate culinary tourism with its suite of offerings. Users can make direct reservations at over 50,000 restaurants worldwide, thanks to seamless integration with leading global booking platforms. Food rankings are also accessible via AI-powered assistant TripGenie and planning hub Trip.Planner on the Trip.com platform, making it easier than ever to weave in dining experiences in your travel itinerary. Beyond reservations, Trip.Gourmet is launching new "travel + food" products that pair dining experiences with hotels or guided tours, enriching the journey for fork-first travellers. Other highlights include celebrity-led food tours in a campaign known as Trip.Gourmet: The Chef's Table, offering culinary journeys hosted by influential chefs and personalities, and the "Taste of China" immersive restaurant experience, a new Shanghai-based, 90-minute dining show that brings together signature dishes from China's seven major culinary regions through panoramic visuals and live performances. These new experiences underscore Trip.com Group's commitment to creative destination storytelling, positioning food as a powerful lens through which to explore culture, memory, and place. About Trip.Gourmet Since 2016, Trip.Gourmet has been dedicated to providing objective and fair food guides amid a vast array of restaurants and diverse user tastes. Leveraging years of user data and authoritative culinary opinions, Trip.Gourmet selects the best dining experiences worldwide. The Trip.Gourmet Global Restaurant Rankings and Dining Awards represents the next step in delivering practical, accurate, and efficient food guides for global travellers. For more information and to explore the top restaurants, visit Trip.com. About Trip.com Group Trip.com Group is a leading global travel service provider comprising of Trip.com, Ctrip, Skyscanner, and Qunar. Across its platforms, Trip.com Group helps travellers around the world make informed and cost-effective bookings for travel products and services and enables partners to connect their offerings with users through the aggregation of comprehensive travel-related content and resources, and an advanced transaction platform consisting of apps, websites and 24/7 customer service centres. Founded in 1999 and listed on NASDAQ in 2003 and HKEX in 2021, Trip.com Group has become one of the best-known travel groups in the world, with the mission "to pursue the perfect trip for a better world". Find out more about Trip.com Group here: group.trip.com. Follow us on: X, Facebook, LinkedIn, and YouTube.
TAIPEI, Nov. 3, 2025 /PRNewswire/ -- QNAP® Systems, Inc., a leading computing, networking and storage solution innovator, today launched the TL-R6020Sep-RP, a 4U 60-bay high-density SAS/SATA JBOD designed to maximize capacity while minimizing costs and rack space. Delivering petabyte-scale storage, the TL-R6020Sep-RP enables enterprises to optimize space utilization, simplify scalability, and ensure reliable long-term data archiving for applications such as cold data, video surveillance, big data, and media archives. QNAP 4U 60-Bay SAS/SATA storage expansion solution — Achieve petabyte-scale capacity with minimal rack space and cost. The TL-R6020Sep-RP provides four high-speed Mini-SAS HD (SFF-8644) ports with SAS 12Gb/s bandwidth and Broadcom® SAS DataBolt™ technology for bandwidth optimization. With its dual-path redundant design, system operation continues uninterrupted even if one cable fails. By supporting daisy-chaining of up to four* enclosures (240 drives total), the TL-R6020Sep-RP allows seamless capacity expansion up to 4PB** raw storage. By adding SAS expansion cards to the NAS and connecting the 60-bay JBOD, users can distribute the bandwidth loads from large drive arrays and further improve overall performance. "With growing volumes of surveillance and big data, enterprises need storage expansion that is both scalable and reliable," said Waterball Liu, Product Manager of QNAP. "The TL-R6020Sep-RP combines petabyte-class capacity and high-density design in a compact 4U chassis, allowing enterprises to expand efficiently, save rack space, and lower operational costs with confidence." Key Features High-density efficiency: Significantly reduces rack space usage, weight, and power consumption, while meeting long-term and large-scale expansion needs. Petabyte-scale capacity: Up to 60x SAS/SATA HDDs in a single 4U chassis, supporting over 1PB** effective capacity. Flexible scalability: Daisy-chain up to four* units with multipath redundancy for 4PB** of raw capacity. Broadcom® SAS DataBolt™ optimization: Aggregates dual 6Gb/s signals into a 12Gb/s stream for faster data throughput. Easy maintenance: Compact 750 mm-deep chassis with included rail kits fits 1000 mm racks, offering hot-swappable fans, power supplies, and drive trays, and front-panel indicators for all 60 drives. Seamless integration and data protection: Manage the JBOD and all drives through QNAP NAS Storage & Snapshots Manager. When paired with ZFS, it provides inline compression, deduplication, and self-healing to ensure data integrity and reliability for petabyte-scale environments. Note: * Actual number of expansion units may depend on the host NAS. ** QNAP calculates raw capacity using sixty 24TB HDDs in a RAID 60 configuration and an over-provisioning of 10%. For more information and specifications, please visit www.qnap.com.
SYDNEY, Nov. 3, 2025 /PRNewswire/ -- Pylon Technologies Co., Ltd. ("Pylontech", SSE: 688063), a global leader in energy storage systems, is pleased to announce the official opening of its Australian subsidiary in Sydney. This milestone represents a major step forward in the company's global expansion strategy and reinforces its long-term commitment to the Australian and New Zealand energy storage markets. The establishment of Pylontech Australia signifies the company's full operational readiness, providing localized sales, technical services, supply chain coordination, and customer support to better serve its partners and clients across the region. "Australia has been one of the most dynamic energy storage markets in the world, and we are proud to have been part of its journey since our first system was installed here over a decade ago," said Geoffrey Song, Vice President of Pylontech. "The launch of Pylontech Australia demonstrates our dedication to supporting local partners through closer collaboration, faster service, and more comprehensive solutions." Australia has become one of the world's most mature and fastest-growing energy storage markets, driven by ambitious national energy transition targets. The government aims to cut emissions by 62–70% below 2005 levels by 2035, supported by programs such as the Cheaper Home Batteries initiative that help households join the clean energy transition. With the new subsidiary now fully operational, Pylontech will further accelerate the delivery of residential, commercial, and utility-scale energy storage solutions — contributing to Australia's progress toward a clean, reliable, and resilient energy future. "By establishing a local presence, we aim to be closer to our customers — not only geographically, but also strategically," added Ned Yu, General Manager of Pylontech Australia. "This milestone enables us to serve the market with even greater agility, innovation, and responsiveness." The opening of Pylontech Australia reaffirms the company's mission to empower global energy transformation through safe, reliable, and sustainable energy storage solutions. About Pylontech Founded in 2009, Pylon Technologies Co., Ltd. (Pylontech, SSE: 688063) is a pioneering and leading energy storage system provider, integrating electrochemistry, power electronics, and system integration technologies. With over 2 million systems deployed globally, Pylontech has earned recognition for its innovation and quality worldwide. The company's product portfolio covers residential, commercial & industrial, and grid-scale applications, supporting global partners in achieving sustainable and secure energy transition.
SHANGHAI, Nov. 3, 2025 /PRNewswire/ -- CARsgen Therapeutics Holdings Limited (Stock Code: 2171.HK), a company focused on developing innovative CAR T-cell therapies, announces clinical data for CT0596, an allogeneic BCMA-targeting CAR-T product candidate developed on its proprietary THANK-u Plus™ platform for relapsed/refractory multiple myeloma (R/R MM), and for CT1190B, an allogeneic CD19/CD20-targeting CAR-T product candidate for relapsed/refractory non-Hodgkin's lymphoma (R/R NHL). The data showed that both allogeneic CAR-T products demonstrated initially favorable safety profiles and encouraging efficacy signals. Data for CT0596 in Relapsed/Refractory Multiple Myeloma CT0596 is a BCMA-targeted allogeneic CAR-T cell therapy candidate developed based on CARsgen's THANK-u Plus™ platform and is currently being evaluated in an investigator-initiated trial (IIT) for malignant plasma cell neoplasms. The study has now entered the dose expansion phase with a determined lymphodepletion regimen. Future work will involve dose escalation of the cells to further determine the Recommended Dose (RD). As of June 24, 2025, the reported clinical trial (NCT06718270) had enrolled 8 R/R MM patients who received CT0596 infusion from the dose-escalation phase. The median number of prior lines of therapy was 4.5 (range: 3-9). Five patients had prior exposure to triple-class drugs (PI, IMiD, and anti-CD38 monoclonal antibody), and five patients had a history of autologous stem cell transplantation. CAR-T cell doses administered were 1.5e8 (n=1), 3e8 (n=5), and 4.5e8 (n=2). All 8 infused patients were evaluable for efficacy, with a median follow-up time of 2.56 months (range: 0.9-5.9 months). For lymphodepletion, 6 patients received fludarabine (30 mg/m²) and cyclophosphamide (500 mg/m²), while 2 patients received a reduced lymphodepletion dose. Five patients achieved partial response (PR) or above: 3 achieved complete response / stringent complete response (CR/sCR) (all of whom had received the full dose of lymphodepletion), 1 achieved PR, and 1 achieved very good partial response (VGPR). Six patients achieved minimal residual disease (MRD)-negativity at Week 4. No patients got progression disease. Pat 01 has ongoing sCR and MRD negative for nearly 6 months. CAR-T cell expansion was observed in all 8 patients. No dose-limiting toxicities (DLT), treatment discontinuations, or deaths were observed. Four patients experienced Grade 1 cytokine release syndrome (CRS), all of which resolved within 2-10 days. Previously, in October 2025, CARsgen announced preliminary clinical data for CT0596 in relapsed/refractory primary plasma cell leukemia (pPCL). Two heavily pretreated pPCL patients with high disease burden and rapid progression both achieved sCR after receiving CT0596 treatment. Data for CT1190B in Relapsed/Refractory Non-Hodgkin's Lymphoma CT1190B is a CD19/CD20-targeted allogeneic CAR-T cell therapy candidate developed based on CARsgen's THANK-u Plus™ platform and is currently being evaluated in multiple IITs for indications including R/R NHL. As of October 17, 2025, this reported clinical trials (NCT07053670, NCT06734871) had enrolled 14 patients, including 3 with follicular lymphoma (FL), 3 with mantle cell lymphoma (MCL), and 8 with diffuse large B-cell lymphoma (DLBCL). The dose escalation study has been completed, preliminarily determining the recommended lymphodepletion regimen and cell dose. At the lymphodepletion dose of Fludarabine 30mg/m²×3 days + Cyclophosphamide 500mg/m²×3 days, all three FL patients achieved CR. One of these FL patients had failed immunochemotherapy, a PI3K inhibitor, chemotherapy + autologous hematopoietic stem cell transplantation, and CD3/CD20 bispecific antibody therapy; another FL patient had failed immunochemotherapy + autologous hematopoietic stem cell transplantation and CD19 CAR-T therapy. The peak copy number of expansion in these three patients reached 10³-10⁴ copies/µg gDNA. At the lymphodepletion dose of Fludarabine 30mg/m²×3 days + Cyclophosphamide 1000mg/m²×2 days (the recommended lymphodepletion dose), 8 patients were enrolled, including 2 MCL patients (cell dose 6e8) and 6 DLBCL patients (cell dose 3e8: 1 patient; 4.5e8: 1 patient; 6e8: 4 patients). The details are below: Six patients were evaluable for efficacy, achieving an ORR of 83.3%, comprising 4 patients who achieved CR (2 MCL, 2 DLBCL) and 1 patient who achieved PR (DLBCL). Focusing on the 6e8 cell dose, 6 patients were enrolled. Four of them were evaluable for efficacy, and 3 achieved a response, all of which were CR. The remaining 2 DLBCL patients had not reached the timepoint for efficacy assessment. A total of 6 patients received the full lymphodepletion and recommended cell dose, with a median Cmax reaching levels on the order of 10⁵ copies/ug gDNA. The primary safety signals of CT1190B were CRS, cytopenia, and infections. Other adverse reactions, such as immune effector cell-associated neurologic syndrome (ICANS) and graft versus host disease (GVHD) were not observed. About CT0596 CT0596 is an allogeneic BCMA-targeted CAR-T therapy developed using CARsgen's proprietary THANK-u Plus™ platform. It is currently being evaluated in investigator-initiated trials for relapsed/refractory multiple myeloma (R/R MM) or plasma cell leukemia (PCL). CT0596 demonstrated preliminary favorable tolerability and encouraging efficacy signals. Further investigation is planned in additional plasma cell malignancies and autoimmune diseases mediated by autoreactive plasma cells. The company anticipates submitting an Investigational New Drug (IND) application in the second half of 2025. About CT1190B CT1190B is a CD19/CD20-targeted allogeneic CAR-T cell therapy developed based on CARsgen's THANK-u Plus™ platform. Ongoing clinical trials include IITs for relapsed/refractory B-cell non-Hodgkin lymphoma (B-NHL), and for moderate-to-severe refractory systemic lupus erythematosus (SLE) or refractory/progressive systemic sclerosis (SSc). About CARsgen Therapeutics Holdings Limited CARsgen is a biopharmaceutical company focusing on developing innovative CAR T-cell therapies to address the unmet clinical needs including but not limited to hematologic malignancies, solid tumors and autoimmune diseases. CARsgen has established end-to-end capabilities for CAR T-cell research and development covering target discovery, preclinical research, product clinical development, and commercial-scale production. CARsgen has developed novel in-house technologies and a product pipeline with global rights to address challenges faced by existing CAR T-cell therapies. Efforts include improving safety profile, enhancing the efficacy in treating solid tumors, and reducing treatment costs, etc. CARsgen's mission is to be a global biopharmaceutical leader that provides innovative and differentiated cell therapies for patients worldwide and makes cancer and other diseases curable. Forward-looking Statements All statements in this press release that are not historical fact or that do not relate to present facts or current conditions are forward-looking statements. Such forward-looking statements express the Group's current views, projections, beliefs and expectations with respect to future events as of the date of this press release. Such forward-looking statements are based on a number of assumptions and factors beyond the Group's control. As a result, they are subject to significant risks and uncertainties, and actual events or results may differ materially from these forward-looking statements and the forward-looking events discussed in this press release might not occur. Such risks and uncertainties include, but are not limited to, those detailed under the heading "Principal Risks and Uncertainties" in our most recent annual report and interim report and other announcements and reports made available on our corporate website, https://www.carsgen.com. No representation or warranty is given as to the achievement or reasonableness of, and no reliance should be placed on, any projections, targets, estimates or forecasts contained in this press release.
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